1,3,5-triazinane-2,4,6-trione derivatives and uses thereof

Patent metadata

Field	Value
Publication number	US-9315472-B2
Application number	US-201414267530-A
Country	US
Kind code	B2
Filing date	May 1, 2014
Priority date	May 1, 2013
Publication date	Apr 19, 2016
Grant date	Apr 19, 2016

Abstract

The present invention provides novel 1,3,5-triazinane-2,4,6-trione derivatives, such as compounds of any one of Formulae (I) and (II), and salts thereof, and methods of preparing the compounds. Also provided are compositions including a compound of the invention and an agent (e.g., an siRNA, mRNA, or plasmid DNA). The present invention also provides methods and kits using the compositions for delivering an agent to a subject (e.g., to the liver, spleen, or lung of the subject) or cell and for treating and/or preventing a range of diseases, such as genetic diseases, proliferative diseases, hematological diseases, neurological diseases, liver diseases, and lung diseases.

First claim

What is claimed is:

1. A compound of Formula (I):

or a salt thereof;
wherein:
each instance of R A is independently substituted or unsubstituted C 6-13 alkyl;
each instance of R B is independently substituted or unsubstituted C 6-13 alkyl; and
each instance of m is independently 1, 2, 3, 4, 5, or 6.

2. The compound of claim 1 ,…

Assignees

• Massachusetts Inst Technology

Inventors

• Dong Yizhou
• Alabi Akinleye C
• Yin Hao
• Dorkin Joseph R
• Chen Delai
• Langer Robert S
• Anderson Daniel Griffith
• Eltoukhy Ahmed A

Classifications

• A61K31/53

  Human Necessities · mapped topic

• A61K31/713

  Human Necessities · mapped topic

• C07D251/30 Primary

  Chemistry & Metallurgy · mapped topic