Magnetic body and drug delivery control device using magnetic body

Patent metadata

Field	Value
Publication number	US-9314602-B2
Application number	US-201013518662-A
Country	US
Kind code	B2
Filing date	Dec 24, 2010
Priority date	Dec 25, 2009
Publication date	Apr 19, 2016
Grant date	Apr 19, 2016

Abstract

A magnetic body may be suitably applied to a drug delivery system using magnetism. Furthermore, a drug delivery control device allows the magnetic body to be suitably applied to drug delivery. The magnetic body includes a magnet and a cover part attached to an edge of the magnet. The cover part is composed of a material with high magnetic permeability, and a ratio of a length to a radius of the cover part is 10:1 to 7:3. The drug delivery control device includes the magnetic body, a head for supporting the magnetic body and a drive mechanism of the head that causes the head to operate along a projected region formed by the affected area with respect to a surface of a tissue. A magnetic field is applied from the magnetic body to the affected area where a magnetic drug is administered.

First claim

The invention claimed is:

1. A magnetic body comprising:
a neodymium magnet having a length, center, and longitudinal axis along the length and the center of the magnet; and
a cover part attached to an edge of the magnet, wherein:
the cover part is composed of a material with high magnetic permeability that includes a permalloy,
a ratio of a length to a radius of the cover part is 10:1 to 7:3,
a side surface of the cover part in a lengthwise direction is formed to be tapered toward a peak of the cover part centered on or about the longitudinal axis, the peak having a rounded shape, which extends from a starting point along the longitudinal axis of the cover part to an upper-most point along the longitudinal axis of the cover part,
the cover part has a bottom surface that is adjacent the edge of the neodymium magnet, and
a radius of the cover part at the starting point is between 1 mm and 30 mm, a height from the bottom surface of the cover part to the starting point is between 5 mm and 15 mm, and a height of the peak from the starting point to the upper-most point is approximately the same as the radius of the cover part at the starting point.

2. A drug delivery control device comprising:
a magnetic body, the magnetic body including:
a neodymium magnet having a length, center, and longitudinal axis along the length and the center of the magnet; and
a cover part attached to an edge of the magnet, wherein:
the cover part comprises a material with high magnetic permeability that includes a permalloy,
a ratio of a length to a radius of the cover part is 10:1 to 7:3, and
a side surface of the cover part in a lengthwise direction is tapered toward a peak of the cover part centered on or about the longitudinal axis, the peak having a rounded shape, which extends from a starting point along the longitudinal axis of the cover part to an upper-most point along the longitudinal axis of the cover part,
the cover part has a bottom surface that is adjacent the edge of the neodymium magnet, and
a radius of the cover part at the starting point is between 1 mm and 30 mm, a height from the bottom surface of the cover part to the starting point is between 5 mm and 15 mm, and a height of the peak from the starting point to the upper-most point is approximately the same as the radius of the cover part at the starting point;

a head including a support mechanism supporting the magnet of the magnetic body; and
an XY direction slide drive mechanism and a Z direction slide drive mechanism connected to the support mechanism of the head that causes the head to operate along a projected region formed by an affected area with respect to a surface of a tissue,
wherein the drug delivery control device applies a magnetic field from the magnetic body to the affected area where a magnetic drug is administered.

3. The drug delivery control device according to claim 2 , comprising: a pressure sensor detecting pressure generated from a peak of the magnetic body to a side of the magnet, wherein the magnetic body concentrates a magnetic flux density at the peak.

4. The drug delivery control device according to claim 3 , wherein the Z direction drive mechanism causes the head to advance toward and retreat from the affected area based on output from the pressure sensor.

5. The drug delivery control device of claim 2 , wherein the Z direction slide mechanism includes a rack along the support mechanism and a pinion, the rack is configured to advance or retreat upon rotation of the pinion, and to cause the head to advance or retreat.

6. The drug delivery control device of claim 5 further comprising a pressure sensor between the magnet and the support mechanism.

7. The drug delivery control device of claim 5 , wherein the drive mechanism is configured to reciprocate over the affected area.

8. The drug delivery control device of claim 5 , wherein the XY drive mechanism is configured to reciprocate over the affected area by positioning the magnetic body toward one side of the affected area for a first period, moving the magnetic body to another side of the affected area for a second period of time, and repeating the positioning and moving steps.

9. The drug delivery control device of claim 8 , wherein the first period is ten minutes and the second period is ten minutes.

10. The drug delivery control device of claim 2 further comprising an arithmetic circuit configured to store diagnostic image information, determine a region where the affected area exists from the diagnostic image information, and calculates a scan trajectory for the head to the affected area.

11. The drug deliver control device of claim 10 , wherein the arithmetic circuit moves the head to an initial position in the XY direction, then causes the head to move in the Z direction toward or away from the affected area, and then moves the head from the initial position in the XY direction to an end-point position along the expected trajectory of the scan.

Assignees

• Ishikawa Yoshihiro
• Eguchi Haruki
• Hara Masakazu
• Ihi Corp

Inventors

• Ishikawa Yoshihiro
• Eguchi Haruki
• Hara Masakazu

Classifications

• H01F7/0205

  Magnetic circuits with PM in general · CPC title

• A61B2090/064

  for measuring force, pressure or mechanical tension · CPC title

• A61M37/00 Primary

  Other apparatus for introducing media into the body (for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30); Percutany, i.e. introducing medicines into the body by diffusion through the skin (salt baths A61H33/04) · CPC title

• A61M31/002

  Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time (artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50) · CPC title

• A61B2034/731

  Arrangement of the coils or magnets · CPC title