Immune function modulating agents

Patent metadata

Field	Value
Publication number	US-9314041-B2
Application number	US-81761706-A
Country	US
Kind code	B2
Filing date	Feb 23, 2006
Priority date	Mar 3, 2005
Publication date	Apr 19, 2016
Grant date	Apr 19, 2016

Abstract

A probiotic lactobacillus was discovered from lactobacilli of the Lactobacillus genus independently isolated from human adult feces. The probiotic lactobacillus was selected from other bacterial strains for: (1) being highly resistant to gastric acid/bile acid; (2) having a high promoting activity on IL-12 production from mouse derived spleen cells and a high Th1/Th2 balance-improving effect; (3) having a high ability to inhibit the production of antigen-specific IgE induced by intraperitoneally administering ovalbumin to BALB/c mice; (4) having a high ability to inhibit the production of antigen-specific IgE induced by orally administering a food antigen to C57BL/6N mice; (5) having a high Natural Killer cell-activating ability; (6) having a high IL-12 production-promoting activity on spleen cells and mesenteric lymph node cells derived from mice immunized with ovalbumin and a high Th1/Th2 balance-improving effect; and (7) having a high ability to suppress eosinophilia induced by a cedar pollen-extracted antigen. This discovery led to the completion of the present invention.

First claim

The invention claimed is:

1. A dietary composition or drink comprising a biologically pure culture of Lactobacillus gasseri OLL2809 deposited under the accession number NITE BP-72 that is in a concentrated form or a dried form, at a content of 0.001% (w/w) or higher, wherein the concentrated form contains 4×10 10 cells/g or higher of said Lactobacillus gasseri OLL2809, or the dried form contains 5×10 11 cells/g or higher of said Lactobacillus gasseri OLL2809.

2. The dietary composition of claim 1 , which comprises a formula milk for infants, food for infants, food for nursing women, health-promoting food, food for people with allergic symptoms, or fermented milk.

Assignees

• Sashihara Toshihiro
• Yamaguchi Makoto
• Nakamura Yoshitaka
• Ikegami Shuji
• Narushima Seiko
• Kimura Katsunori
• Nagafuchi Shinya
• Terahara Masaki
• Meiji Co Ltd

Inventors

• Sashihara Toshihiro
• Yamaguchi Makoto
• Nakamura Yoshitaka
• Ikegami Shuji
• Narushima Seiko
• Kimura Katsunori
• Nagafuchi Shinya
• Terahara Masaki

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P37/08

  Antiallergic agents (antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14) · CPC title

• A61P37/02

  Immunomodulators · CPC title

• A61K35/747

  Lactobacilli, e.g. L. acidophilus or L. brevis · CPC title

• A23C9/1234

  characterised by using a Lactobacillus sp. other than Lactobacillus Bulgaricus, including Bificlobacterium sp. · CPC title