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Chimeric rat produced using rat embryonic stem cells in the presence of an ES cell differentiation suppressant
US9309537B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9309537-B2 |
| Application number | US-201013513100-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 30, 2010 |
| Priority date | Dec 1, 2009 |
| Publication date | Apr 12, 2016 |
| Grant date | Apr 12, 2016 |
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Abstract
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The present invention provides a preparation method of a chimeric embryo and a chimeric rat, which is characterized by contacting a rat pluripotent stem cell and a host embryo in the presence of an ES cell differentiation inhibitor. The method includes (a) a step for contacting a fertilized host embryo collected from a female rat and a rat pluripotent stem cell in the presence of an ES cell differentiation suppressant, and (b) a step for culturing the host embryo in contact with the rat pluripotent stem cell to form a chimeric embryo.
First claim
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The invention claimed is: 1. A method of preparing a chimeric embryo, comprising (a) a step for introducing a rat pluripotent stem cell into a fertilized host embryo collected from a female rat, wherein the introducing is in a medium comprising an ES cell differentiation suppressant comprising an MEK inhibitor, a GSK3 inhibitor, and a TGFβ receptor inhibitor, to produce a chimeric rat embryo. 2. The method according to claim 1 , wherein the introducing is ac…
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Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Human Necessities · mapped topic
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- What does patent US9309537B2 cover?
- The present invention provides a preparation method of a chimeric embryo and a chimeric rat, which is characterized by contacting a rat pluripotent stem cell and a host embryo in the presence of an ES cell differentiation inhibitor. The method includes (a) a step for contacting a fertilized host embryo collected from a female rat and a rat pluripotent stem cell in the presence of an ES cell dif…
- Who is the assignee on this patent?
- Ochiya Takahiro, Kawamata Masaki, Nat Cancer Ct, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification C12N15/873. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Apr 12 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).