Methods for monopolar renal neuromodulation

Patent metadata

Field	Value
Publication number	US-9308043-B2
Application number	US-201414548810-A
Country	US
Kind code	B2
Filing date	Nov 20, 2014
Priority date	Apr 8, 2002
Publication date	Apr 12, 2016
Grant date	Apr 12, 2016

Abstract

Methods and apparatus are provided for monopolar neuromodulation, e.g., via a pulsed electric field. Such monopolar neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, monopolar neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such monopolar neuromodulation is performed bilaterally.

First claim

We claim:

1. A method for treating diagnosed hypertension by renal neuromodulation of a human patient, the method comprising:
placing a monopolar electrode within renal vasculature and in contact with a vessel wall of the renal vasculature of the patient, wherein the monopolar electrode is proximate to a post-ganglionic nerve innervating a kidney of the patient;
electrically coupling a ground electrode to an exterior of the patient; and
delivering an electric field between the monopolar electrode and the ground electrode to reduce neural communication along the post-ganglionic nerve,
wherein delivering the electric field results in a therapeutically beneficial reduction in blood pressure of the patient.

2. The method of claim 1 wherein reducing neural communication along the post-ganglionic nerve comprises ablating the nerve.

3. The method of claim 1 wherein reducing neural communication along the post-ganglionic nerve comprises partially ablating the nerve.

4. A method for treating a human patient with diagnosed hypertension via renal neuromodulation, the method comprising:
placing a monopolar electrode within a renal artery of the patient, wherein the monopolar electrode is adjacent to a post-ganglionic nerve innervating a kidney of the patient;
coupling a ground electrode to an exterior of the patient; and
delivering an electric field between the monopolar electrode and the ground electrode, wherein the electric field reduces neural communication along the post-ganglionic nerve,
wherein delivering the electric field results in a therapeutically beneficial reduction in blood pressure of the patient.

5. The method of claim 4 wherein placing a monopolar electrode within a renal artery of the patient comprising intravascularly delivering the electrode to the renal artery via a femoral artery and an aorta of the patient.

6. The method of claim 4 wherein reducing neural communication along the post-ganglionic nerve comprises blocking neural traffic to and/or from the kidney.

7. The method of claim 4 wherein reducing neural communication along the post-ganglionic nerve comprises attenuating afferent neural traffic to and/or from the kidney.

8. The method of claim 4 wherein reducing neural communication along the post-ganglionic nerve comprises attenuating efferent neural traffic to and/or from the kidney.

9. The method of claim 4 wherein the monopolar electrode is carried by an expandable basket, and wherein placing a monopolar electrode within a renal artery of the patient comprises delivering the expandable basket to the renal artery in a low-profile configuration and transforming the basket to a deployed configuration to place the electrode in contact with a wall of the renal artery.

10. The method of claim 4 , further comprising monitoring a parameter of tissue within the patient before and during delivery of the electric field.

11. The method of claim 10 , further comprising modifying delivery of the electric field in response to the monitored parameter.

12. The method of claim 4 wherein reducing neural communication along the post-ganglionic nerve comprises ablating the post-ganglionic nerve.

13. The method of claim 4 wherein reducing neural communication along the post-ganglionic nerve comprises partially ablating the post-ganglionic nerve.

14. The method of claim 4 wherein placing a monopolar electrode within a renal artery of the patient comprises:
positioning an expandable member carrying two or more electrodes within the renal artery in a low-profile delivery arrangement; and
transforming the expandable member into a treatment arrangement to place the two or more electrodes in apposition with a wall of the renal artery before delivering the electric field.

15. The method of claim 14 wherein the expandable member comprises a balloon.

16. The method of claim 4 wherein placing a monopolar electrode within a renal artery of the patient comprises placing the electrode in contact with a vessel wall of the renal artery adjacent to the post-ganglionic nerve.

17. The method of claim 4 , further comprising removing the monopolar electrode from the patient after delivering the electric field.

18. A method for catheter-based renal neuromodulation, the method comprising:
intravascularly positioning a catheter having a monopolar electrode within a renal artery of a human patient and in vicinity of renal nerves innervating a kidney of the patient; and
reducing neural communication to and from the kidney by ablating the renal nerves of the patient via electrical energy delivered between the monopolar electrode and a ground pad on the skin of the patient,
wherein reducing neural communication to and from the kidney results in improved cardio-renal function of the patient.

19. The method of claim 18 wherein intravascularly positioning a catheter having a monopolar electrode within a renal artery of the patient comprises intravascularly delivering the catheter to the renal artery via a guidewire.

20. The method of claim 18 wherein the catheter comprises a basket with a plurality of struts and monopolar electrodes on each strut, and wherein intravascularly positioning a catheter having a monopolar electrode within a renal artery comprises intravascularly delivering the basket to the renal artery in a delivery arrangement and transforming the basket to a deployed configuration to place the monopolar electrodes carried by the struts in apposition with an inner wall of the renal artery.

21. The method of claim 18 wherein reducing neural communication to and from the kidney by ablating the renal nerves of the patient comprises thermally altering the renal nerves via the electrical energy.

22. The method of claim 18 , further comprising removing the catheter from the patient after ablating the renal nerves.

Assignees

• Medtronic Ardian Luxembourg

Inventors

• Zarins Denise
• Gifford Iii Hanson
• Deem Mark
• Levin Howard R
• Gelfand Mark
• Zadno Nicolas

Classifications

• A61B2018/00511

  Kidney · CPC title

• A61B2018/00577

  Ablation · CPC title

• A61B2018/1435

  Spiral · CPC title

• A61N1/0551

  Spinal or peripheral nerve electrodes · CPC title

• A61B5/4848

  Monitoring or testing the effects of treatment, e.g. of medication · CPC title