Micropore forming apparatus and micropore forming method

Patent metadata

Field	Value
Publication number	US-9307933-B2
Application number	US-201113161910-A
Country	US
Kind code	B2
Filing date	Jun 16, 2011
Priority date	Jun 24, 2010
Publication date	Apr 12, 2016
Grant date	Apr 12, 2016

Abstract

To provide a micropore forming apparatus capable of increasing the amount of interstitial fluid extracted from micropores formed in the skin of a subject. The micropore forming apparatus includes a skin contact part that has a plurality of microneedles for piercing the skin of the subject, and a force exerting part for exerting a force on the skin contact part toward the skin of the subject. The force exerting part is configured so as to exert a force on the microneedles toward the skin at a position at which the microneedles of the skin contact part are to pierce the skin of the subject.

First claim

What is claimed is:

1. A micropore forming apparatus for forming micropores in the skin by piercing the skin of a subject with microneedles comprising:
a skin contact part that has a plurality of microneedles for piercing the skin of the subject; and
a spring for exerting a force on the skin contact part toward the skin of the subject;
wherein the spring has a length so as to maintain the state of compression of the spring and thereby maintain the state of the microneedles being pressed into the skin after the microneedles have initially pierced the skin of the subject,
wherein, after the microneedles have pierced the skin, the spring exerts a force P (Pa) on the skin through the microneedles such that 2.56×10 5 ≦P.

2. The micropore forming apparatus of claim 1 , wherein the speed S (m/s) of the microneedles piercing the skin is set such that 4.8≦S.

3. The micropore forming apparatus of claim 1 , wherein the speed S (m/s) of the microneedles piercing the skin is set such that S is ≦6.1.

4. A micropore forming method for forming micropores in the skin of a subject using a micropore forming apparatus for forming micropores in the skin by piercing the skin of the subject with microneedles;
wherein the micropore forming apparatus comprises:
a skin contact part that has a plurality of microneedles for piercing the skin of the subject; and
a spring for exerting a force on the skin contact part toward the skin of the subject;
wherein the spring has a length so as to maintain the state of compression of the spring and thereby maintain the state of the microneedles being pressed into the skin after the microneedles have initially pierced the skin of the subject,
the method further comprising collecting interstitial fluid extracted from the micropores by an extraction medium.

5. The micropore forming method of claim 4 , wherein the predetermined time is 0.15 second or longer.

6. The micropore forming method of claim 5 , wherein the predetermined time is 60 seconds or less.

7. The micropore forming method of claim 4 , wherein the speed S (m/s) of the microneedles piercing the skin is set such that 4.8≦S.

8. The micropore forming method of claim 4 , wherein the speed S (m/s) of the microneedles piercing the skin is set such that S≦6.1.

9. The micropore forming method of claim 4 , wherein, after the microneedles have pierced the skin, the spring exerts a force P (Pa) on the skin through the microneedles such that 2.56×10 5 ≦P.

Assignees

• Kikkawa Yasuo
• Sato Toshiyuki
• Sysmex Corp

Inventors

• Kikkawa Yasuo
• Sato Toshiyuki

Classifications

• A61B5/1513

  comprising linear sliding guides (comprising tooth-shaped elements A61B5/15132) · CPC title

• A61B5/14514

  using means for aiding extraction of interstitial fluid, e.g. microneedles or suction · CPC title

• A61B5/15117

  comprising biased elements, resilient elements or a spring, e.g. a helical spring, leaf spring, or elastic strap · CPC title

• A61B5/15194

  fully automatically retracted, i.e. the retraction does not require a deliberate action by the user, e.g. by terminating the contact with the patient's skin · CPC title

• A61B5/1519

  comprising driving means, e.g. a spring, for propelling the piercing unit · CPC title