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Methods, apparatus and systems for production, collection, handling, and imaging of tissue sections
US9304067B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9304067-B2 |
| Application number | US-201313734121-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 4, 2013 |
| Priority date | Jul 8, 2004 |
| Publication date | Apr 5, 2016 |
| Grant date | Apr 5, 2016 |
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Abstract
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Methods, apparatus and systems for collecting thin tissue samples for imaging. Thin tissue sections may be cut from tissue samples using a microtome-quality knife. In one example, tissue samples are mounted to a substrate that is rotated such that thin tissue sections are acquired via lathing. Collection of thin tissue sections may be facilitated by a conveyor belt. Thin tissue sections may be mounted to a thin substrate (e.g., by adhering thin tissue sections to a thin substrate via a roller mechanism) that may be imaged, for example, by an electron beam (e.g., in an electron microscope). Thin tissue sections may be strengthened before cutting via a blockface thinfilm deposition technique and/or a blockface taping technique. An automated reel-to-reel imaging technique may be employed for collected/mounted tissue sections to facilitate random-access imaging of tissue sections and maintaining a comprehensive library including a large volume of samples.
First claim
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What is claimed is: 1. A system for processing a tissue sample, the system comprising: a cutting portion including: a cutting surface for contacting the tissue sample so as to liberate a thin tissue section that includes at least a portion of the tissue sample, and a water bath constructed and arranged to contain water having a surface for supporting the thin tissue section; and a collecting portion including: a conductive support tape for collecting the thin tissue sectio…
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- What does patent US9304067B2 cover?
- Methods, apparatus and systems for collecting thin tissue samples for imaging. Thin tissue sections may be cut from tissue samples using a microtome-quality knife. In one example, tissue samples are mounted to a substrate that is rotated such that thin tissue sections are acquired via lathing. Collection of thin tissue sections may be facilitated by a conveyor belt. Thin tissue sections may be …
- Who is the assignee on this patent?
- Hayworth Kenneth Jeffrey, Hayworth Amy Au, Harvard College
- What technology area does this patent fall under?
- Primary CPC classification G01N1/286. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Apr 05 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).