Compositions for saccharification of cellulosic material
US-2024018560-A1 · Jan 18, 2024 · US
Mutant L-arabitol dehydrogenase derived from neurospora crassa with enhanced activity
US9303278B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9303278-B2 |
| Application number | US-201314364631-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 18, 2013 |
| Priority date | May 10, 2012 |
| Publication date | Apr 5, 2016 |
| Grant date | Apr 5, 2016 |
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- Title
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Abstract
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The present invention is to enhance the stability and enzyme activity of an L-arabitol dehydrogenase derived from Neurospora crassa using techniques from quantum mechanics and molecular mechanics and partial mutation techniques. More specifically, the present invention relates to a method for preparing an L-arabitol dehydrogenase in which a residue which affects enzyme stability is found through a screening based on quantum mechanics and molecular mechanics, and enzyme activity is enhanced by mutation of the found residue, nucleic acid molecules encoding the L-arabitol dehydrogenase, a vector including the nucleic acid molecules, a transformant including the vector, a mutant of the L-arabitol dehydrogenase and an improved L-arabitol dehydrogenase.
First claim
Opening claim text (preview).
What is claimed is: 1. A mutant L-arabitol dehydrogenase consisting of the amino acid sequence as set forth in SEQ ID NO:13.
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Classifications
L-Arabinitol 4-dehydrogenase (1.1.1.12) · CPC title
- C12P19/02Primary
Monosaccharides (2-ketogulonic acid C12P7/60) · CPC title
acting on CH-OH groups as donors (1.1) · CPC title
- C12N9/0004Primary
Oxidoreductases (1.) · CPC title
Preparation of compounds containing saccharide radicals (ketoaldonic acids C12P7/58) · CPC title
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- What does patent US9303278B2 cover?
- The present invention is to enhance the stability and enzyme activity of an L-arabitol dehydrogenase derived from Neurospora crassa using techniques from quantum mechanics and molecular mechanics and partial mutation techniques. More specifically, the present invention relates to a method for preparing an L-arabitol dehydrogenase in which a residue which affects enzyme stability is found thro…
- Who is the assignee on this patent?
- Univ Konkuk Ind Coop Corp
- What technology area does this patent fall under?
- Primary CPC classification C12P19/02. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Apr 05 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).