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Pyrazol-3-ones that activate pro-apoptotic BAX
US9303024B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9303024-B2 |
| Application number | US-201214350847-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 11, 2012 |
| Priority date | Oct 11, 2011 |
| Publication date | Apr 5, 2016 |
| Grant date | Apr 5, 2016 |
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Abstract
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This application features pyrazol-3-one compounds that activate pro-apoptotic BAX. Also featured are methods of using such compounds, e.g., for the treatment or prevention of diseases, disorders, and conditions associated with deregulated apoptosis of cells (e.g., insufficient apoptosis of diseased or damaged cells or essentially the absence of apoptosis of diseased or damaged cells).
First claim
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What is claimed is: 1. A compound of formula (I-A), or a pharmaceutically acceptable salt thereof: wherein: X′ is S; X′″ is unsubstituted phenyl, X″ is H or C 1 -C 4 alkyl; R 2 is: C 1 -C 4 alkyl; or phenyl that is optionally substituted with from 1-4 R e ; or heteroaryl containing from 5-6 ring atoms, wherein from 1-4 of the ring atoms is independently sel…
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Human Necessities · mapped topic
Chemistry & Metallurgy · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
- C07D417/04Primary
Chemistry & Metallurgy · mapped topic
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- What does patent US9303024B2 cover?
- This application features pyrazol-3-one compounds that activate pro-apoptotic BAX. Also featured are methods of using such compounds, e.g., for the treatment or prevention of diseases, disorders, and conditions associated with deregulated apoptosis of cells (e.g., insufficient apoptosis of diseased or damaged cells or essentially the absence of apoptosis of diseased or damaged cells).
- Who is the assignee on this patent?
- Dana Farber Cancer Inst Inc, Dana Farber Cancer Inst Inc
- What technology area does this patent fall under?
- Primary CPC classification C07D417/04. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Apr 05 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).