Hemostatic compositions and methods of use

Patent metadata

Field	Value
Publication number	US-9302025-B2
Application number	US-201414198395-A
Country	US
Kind code	B2
Filing date	Mar 5, 2014
Priority date	Feb 21, 2007
Publication date	Apr 5, 2016
Grant date	Apr 5, 2016

Abstract

Hemostatic compositions comprising a wet layered clay (e.g., wet kaolin) and, optionally, a zeolite, as well as devices and methods of use to promote blood clotting, are provided.

First claim

What is claimed is:

1. A device containing a hemostatic composition, the device comprising:
a sterile container; and
a hemostatic composition comprising a hemostatically effective amount of a wet layered clay selected from the group consisting of a kaolin, a palygorskite and a sepiolite, wherein the clay is not vitrified, and wherein the hemostatic composition is provided in the sterile container, is hydrated from 0.5 wt. % to 30 wt. %, and does not include a zeolite.

2. The device of claim 1 , wherein the wet layered clay is kaolin.

3. The device of claim 1 , wherein the wet layered clay is combined with a clotting factor polypeptide or a thrombin polypeptide.

4. A hemostatic composition comprising:
a hemostatically effective amount of an isolated wet layered clay selected from the group consisting of a kaolin, a smectite, a palygorskite and a sepiolite, wherein the clay is not vitrified; and
an isolated zeolite;
wherein the wet layered clay and the zeolite are present in a 3:1 ratio (w/w) and provide for hemostatic activity of the composition.

5. The hemostatic composition of claim 4 , wherein the zeolite is at least partially dehydrated.

6. The hemostatic composition of claim 5 , wherein the zeolite has a moisture content of from 1 wt. % to 10 wt. % water.

7. The hemostatic composition of claim 5 , wherein the zeolite has a moisture content of 1 wt. % to 4 wt. % water.

8. The hemostatic composition of claim 4 , wherein the zeolite is disposed in a binder.

9. The hemostatic composition of claim 4 , wherein the hemostatic composition is disposed on at least one surface of a device adapted for delivery of the isolated layered clay to a bleeding wound.

10. The hemostatic composition of claim 9 , wherein the device is a bandage or a medical sponge.

11. A method of forming a hemostatic composition, said method comprising:
combining a zeolite with hemostatically effective amount of a wet layered clay selected from the group consisting of a kaolin, a smectite, a palygorskite and a sepiolite, wherein the clay is not vitrified; and
wherein said combining forms a hemostatic composition with a 3:1 ratio (w/w) of the clay to the zeolite.

12. The method of claim 11 , wherein the zeolite is at least partially dehydrated prior to said combining.

13. A method of clotting blood flowing from a wound, the method comprising:
applying the hemostatic composition of claim 1 to a bleeding wound of a subject; and
maintaining the hemostatic composition in contact with the wound for a period of time sufficient to at least initiate blood clotting.

14. The hemostatic composition of claim 4 , wherein the clay is kaolin.

15. The hemostatic composition of claim 4 , wherein the clay is a smectite.

16. The hemostatic composition of claim 15 , wherein the smectite is a montmorillonite.

Assignees

• Univ California

Inventors

• Baker Sarah
• Sawvel April
• Stucky Galen D

Classifications

• A61L15/425

  Porous materials, e.g. foams or sponges · CPC title

• A61L15/18 Primary

  containing inorganic materials · CPC title

• A61L15/44

  Medicaments · CPC title

• A61L15/32

  Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin {(A61L15/225 takes precedence)} · CPC title

• A61L2400/04

  Materials for stopping bleeding · CPC title