Low surfactant iodine topical disinfectant

Patent metadata

Field	Value
Publication number	US-9302007-B2
Application number	US-201214005725-A
Country	US
Kind code	B2
Filing date	Mar 23, 2012
Priority date	Mar 25, 2011
Publication date	Apr 5, 2016
Grant date	Apr 5, 2016

Abstract

Iodine-containing germicidal compositions are disclosed that remain physically stable for extended storage periods with little to no iodine complexing agent being present. The compositions employ a mixture of emollients, such as glycerin and ethoxylanolin, to create a composition that in certain embodiments presents a cloudy or emulsion-like appearance.

First claim

I claim:

1. A ready-to-use germicidal composition comprising:
from about 25 to about 50% by weight of a primary emollient selected from the group consisting of glycerin, propylene glycol, sorbitol, polyethylene glycol, and mixtures thereof;
from about 0.05 to about 10% by weight of a water-soluble lanolin derivative; and
from about 0.05 to about 1.5% by weight of iodine, wherein the weight ratio of iodine to said water-soluble lanolin derivative is from about 0.3 to about 10;
said composition comprising less than 1% by weight of iodine complexing surfactants and iodine complexing polymers, wherein the weight ratio of iodine to total iodine complexing surfactants and iodine complexing polymers is greater than 0.5,
said composition being ready to apply to an animal's teat without further dilution.

2. The germicidal composition according to claim 1 , wherein said composition further comprises a thickener.

3. The germicidal composition according to claim 2 , wherein said thickener comprises up to 5% by weight of said composition and is selected from the group consisting of hydroxy ethylcellulose and carboxy methylcellulose, sodium alginate, xanthan gum, gum arabic, and mixtures thereof.

4. The germicidal composition according to claim 1 , wherein said water-soluble lanolin derivative comprises an alkoxylated lanolin.

5. The germicidal composition according to claim 4 , wherein said alkoxylated lanolin comprises ethoxylated lanolin.

6. The germicidal composition according to claim 1 , wherein said primary emollient comprises glycerin.

7. The germicidal composition according to claim 1 , wherein said composition has a viscosity of between about 2 to about 5000 cP.

8. The germicidal composition according to claim 1 , wherein said composition comprises particles suspended therein, said suspended particles having an average diameter of between about 25 nm to about 5 μm.

9. A ready-to-use germicidal composition comprising:
from about 25 to about 50% by weight of a primary emollient selected from the group consisting of glycerin, propylene glycol, sorbitol, polyethylene glycol, and mixtures thereof;
a secondary emollient selected from the group consisting of water-soluble lanolin derivatives, said secondary emollient being present in an amount less than said primary emollient, wherein the weight ratio of iodine to said secondary emollient is from about 0.05 to about 41, wherein the weight ratio of said primary emollient to said secondary emollient is greater than 5;
at least about 0.2% by weight of at least one thickener; and
from about 0.05 to about 1.5% by weight of iodine,
said composition comprising less than 1% by weight of iodine complexing surfactants and iodine complexing polymers, wherein the weight ratio of iodine to total iodine complexing surfactants and iodine complexing polymers is greater than 0.5,
said composition being storage stable for at least one month and ready to apply to an animal's teat without further dilution.

10. The germicidal composition according to claim 9 , wherein said thickener comprises up to 5% by weight of said composition and is selected from the group consisting of hydroxy ethylcellulose and carboxy methylcellulose, sodium alginate, xanthan gum, gum arabic, and mixtures thereof.

11. The germicidal composition according to claim 9 , wherein said water-soluble lanolin derivative comprises an alkoxylated lanolin.

12. The germicidal composition according to claim 11 , wherein said alkoxylated lanolin comprises ethoxylated lanolin.

13. The germicidal composition according to claim 9 , wherein said primary emollient comprises glycerin.

14. The germicidal composition according to claim 9 , wherein said composition comprises particles suspended therein, said suspended particles having an average diameter of between about 25 nm to about 5 μm.

15. A ready-to-use germicidal composition comprising:
from about 0.05 to about 1.5% by weight of iodine,
from 0.05 to about 10% by weight of water-soluble lanolin derivative, wherein the weight ratio of iodine to said water-soluble lanolin derivative is from about 0.3 to about 3,
wherein said composition comprises less than 0.5% by weight of iodine complexing surfactants and iodine complexing polymers, wherein the weight ratio of iodine to total iodine complexing surfactants and iodine complexing polymers is greater than 0.5; and
at least about 0.2% by weight of at least one gum thickener,
said composition being storage stable for at least one month and ready to apply to an animal's teat without further dilution.

16. The germicidal composition according to claim 15 , wherein said at least one gum thickener comprises a mixture of at least two gums.

17. The germicidal composition according to claim 16 , wherein said at least one gum thickener comprises gum arabic and xanthan gum.

18. The germicidal composition according to claim 17 , wherein said at least one gum thickener comprises from about 0.1 to 5% by weight of gum arabic and from about 0.05 to 0.5% by weight of xanthan gum.

19. The germicidal composition according to claim 15 , wherein said water-soluble lanolin derivative comprises an alkoxylated lanolin.

20. The germicidal composition according to claim 19 , wherein said alkoxylated lanolin comprises ethoxylated lanolin.

21. The germicidal composition according to claim 15 , wherein said composition exhibits a viscosity of between about 30 to about 5000 Cps.

22. The germicidal composition according to claim 15 , wherein said composition comprises particles suspended therein, said suspended particles having an average diameter of between about 25 nm to about 5 μm.

23. A method of protecting a bovine teat from infection comprising applying to said bovine teat a quantity of a composition according to claim 9 .

Assignees

• Henderson Mark
• Delaval Holding Ab

Inventors

• Henderson Mark

Classifications

• A61K33/18

  Iodine; Compounds thereof · CPC title

• A61K47/10 Primary

  Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers · CPC title

• A61P17/00

  Drugs for dermatological disorders · CPC title

• A01N59/12 Primary

  Iodine, e.g. iodophors; Compounds thereof · CPC title

• A01N25/04

  Dispersions, {emulsions, suspoemulsions, suspension concentrates} or gels (foams A01N25/16) · CPC title