Use of electrospun microtubes for drug delivery

Patent metadata

Field	Value
Publication number	US-9297094-B2
Application number	US-91837709-A
Country	US
Kind code	B2
Filing date	Feb 12, 2009
Priority date	Feb 21, 2008
Publication date	Mar 29, 2016
Grant date	Mar 29, 2016

Abstract

Provided is a method of delivering a medicament or a diagnostic agent to a subject in need thereof by (a) introducing a microtube configured to deliver the medicament or the diagnostic agent into the subject, said microtube comprises an electrospun shell and an electrospun coat over an internal surface of said shell, and (b) administering the medicament or the diagnostic agent through said microtube, thereby delivering the medicament or the diagnostic agent to the subject. Also provided are kits for delivering a medicament or a diagnostic agent.

First claim

What is claimed is:

1. A kit for delivering a medicament or a diagnostic agent, comprising:
(i) a coupling element, and;
(ii) an infusion microtube which comprises an electrospun shell and an electrospun coat over an internal surface of said shell, wherein said electrospun shell and said electrospun coat are each composed of a polymer.

2. A kit for delivering a medicament or a diagnostic agent, comprising:
(i) a reservoir which comprises the medicament, and;
(ii) an infusion microtube which comprise an electrospun shell and an electrospun coat over an internal surface of said shell, wherein said electrospun shell and said electrospun coat are each composed of a polymer.

3. A method of delivering a medicament or a diagnostic agent to a subject in need thereof, comprising:
(a) introducing a microtube configured to deliver the medicament or the diagnostic agent into the subject, said microtube comprises an electrospun shell and an electrospun coat over an internal surface of said shell, wherein said electrospun shell and said electrospun coat are each composed of a polymer; and
(b) administering the medicament or the diagnostic agent through said microtube,
thereby delivering the medicament or the diagnostic agent to the subject.

4. The method of claim 3 , wherein said microtube is attached to a coupling element.

5. The method of claim 3 , wherein said microtube is connected to a reservoir which comprises the medicament or the diagnostic agent.

6. The method of claim 5 , wherein said reservoir is connected to a pump.

7. The method of claim 5 , wherein said reservoir is connected to or comprises a filter.

8. The method of claim 5 , wherein said reservoir is connected to said coupling element.

9. The method of claim 3 , wherein said microtube is produced by co-electrospinning two polymeric solutions through co-axial capillaries, wherein a first polymeric solution of said two polymeric solutions is for forming a shell of the microtube and a second polymeric solution of said two polymeric solutions is for forming a coat over an internal surface of said shell, said first polymeric solution is selected solidifying faster than said second polymeric solution and a solvent of said second polymeric solution is selected incapable of dissolving said first polymeric solution.

10. The method of claim 9 , wherein a solvent of said first polymeric solution evaporates faster than a solvent of said second polymeric solution.

11. The method of claim 3 , wherein said introducing is effected by implanting said microtube in a subject in need thereof.

12. The method of claim 11 , wherein said implanting is effected at or in proximity to a tissue-of-interest.

13. The method of claim 5 , wherein said reservoir is an implantable reservoir.

14. The method of claim 5 , wherein said reservoir is attached on a skin of the subject in need thereof.

15. The method of claim 3 , wherein said electrospun shell is formed of a first polymeric solution and said electrospun coat is formed of a second polymeric solution.

16. The method of claim 15 , wherein said first polymeric solution solidifies faster than said second polymeric solution.

17. The method of claim 15 , wherein a solvent of said second polymeric solution is incapable of dissolving said first polymeric solution.

18. The method of claim 3 , wherein a thickness of said shell is from about 100 nm to about 20 micrometer.

19. The method of claim 3 , wherein an internal diameter of said microtube is from about 50 nm to about 20 micrometer.

20. The method of claim 3 , wherein said shell comprises pores.

21. The method of claim 3 , wherein said microtube comprises a length of about 5-20 centimeters (cm).

22. The method of claim 3 , wherein said microtube comprises a plurality of microtubes.

23. The method of claim 22 , wherein said plurality of microtubes are attached to a coupling element.

24. The method of claim 22 , wherein said plurality of microtubes are connected to a reservoir which comprises the medicament or the diagnostic agent.

25. A kit for delivering a medicament or a diagnostic agent, comprising:
(i) a coupling element, and;
(ii) an infusion microtube which comprises an electrospun shell and an electrospun coat over an internal surface of said shell, wherein said electrospun shell and said electrospun coat are each composed of a polymer, and wherein said shell comprises pores.

26. A kit for delivering a medicament or a diagnostic agent, comprising:
(i) a reservoir which comprises the medicament, and;
(ii) an infusion microtube which comprise an electrospun shell and an electrospun coat over an internal surface of said shell, wherein said electrospun shell and said electrospun coat are each composed of a polymer, and wherein said shell comprises pores.

27. A method of delivering a medicament or a diagnostic agent to a subject in need thereof, comprising:
(a) introducing a microtube configured to deliver the medicament or the diagnostic agent into the subject, said microtube comprises an electrospun shell and an electrospun coat over an internal surface of said shell, wherein said electrospun shell and said electrospun coat are each composed of a polymer, and wherein said shell comprises pores; and
(b) administering the medicament or the diagnostic agent through said microtube,
thereby delivering the medicament or the diagnostic agent to the subject.

28. A method of delivering a medicament or a diagnostic agent to a subject in need thereof, comprising:
(a) co-electrospinning two polymeric solutions through co-axial capillaries, wherein a first polymeric solution of said two polymeric solutions is for forming a shell of the microtube and a second polymeric solution of said two polymeric solutions is for forming a coat over an internal surface of said shell, said first polymeric solution is selected solidifying faster than said second polymeric solution and a solvent of said second polymeric solution is selected incapable of dissolving said first polymeric solution, and
(b) introducing said microtube resultant of step (a) into the subject, wherein said microtube is configured to deliver the medicament or the diagnostic agent; and
(c) administering the medicament or the diagnostic agent through said microtube,
thereby delivering the medicament or the diagnostic agent to the subject.

Assignees

• Zussman Eyal
• Technion Res & Dev Foundation

Inventors

• Zussman Eyal

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• C02F3/34

  characterised by the microorganisms used · CPC title

• C02F3/342

  characterised by the enzymes used · CPC title

• C12Y114/16001

  Phenylalanine 4-monooxygenase (1.14.16.1) · CPC title

• A61K38/44

  Oxidoreductases (1) · CPC title