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Method for the preparation of nicotinic acid
US9297030B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9297030-B2 |
| Application number | US-201213979673-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 16, 2012 |
| Priority date | Jan 14, 2011 |
| Publication date | Mar 29, 2016 |
| Grant date | Mar 29, 2016 |
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Abstract
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A method for the preparation of nicotinic acid, which includes the step of obtaining a culture solution containing quinolinic acid by incubating a microorganism having an ability to produce quinolinic acid, and the step of adding an acid to the culture solution and conducting a decarboxylation reaction.
First claim
Opening claim text (preview).
The invention claimed is: 1. A method for the preparation of nicotinic acid, which comprises the steps of: obtaining a culture solution containing quinolinic acid by incubating a microorganism having an ability to produce quinolinic acid, in which the activity of quinolinate phosphoribosyltransferase is decreased relative to the wild-type or deleted and the activities of aspartate oxidase and quinolinate synthetase are increased relative to the wild-type; and adding an acid to the culture solution to decarboxylate quinolinic acid, wherein the microorganism having an ability to produce quinolinic acid belongs to Enterbacter genus, Escherichia genus, Erwinia genus, Serratia genus, Providencia genus, Corynebacterium genus or Brevibacterium genus. 2. The method according to claim 1 , wherein the activity of quinolinate phosphoribosyltransferase of the microorganism is decreased relative to the wild-type or deleted by substituting a gene encoding the quinolinate phosphoribosyltransferase with a gene mutated to decrease the activity of quinolinate phosphoribosyltransferase, replacing an endogenous promoter for the gene with a promoter having weakened activity, or deleting the gene from chromosome. 3. The method according to claim 1 , wherein the activities of aspartate oxidase and/or quinolinate synthetase of the microorganism are increased relative to the wild-type by increasing the intracellular copy number of genes encoding the aspartate oxidase and/or quinolinate synthetase, modifying expression regulatory sequences of the genes, or substituting the genes encoding the aspartate oxidase and/or quinolinate synthetase with genes mutated to increase the activities of aspartate oxidase and/or quinolinate synthetase. 4. The method according to claim 1 , wherein the microorganism is a strain belonging to Escherichia genus. 5. The method according to claim 1 , wherein the microorganism is Escherichia coli. 6. The method according to claim 1 , wherein the microorganism is Escherichia coli deposited under accession number KCCM11165P. 7. The method according to claim 1 , wherein the acid added to the culture solution is hydrochloric acid or sulfuric acid. 8. The method according to claim 1 , wherein after addition of an acid, the culture solution has a pH value of 5 or less. 9. The method according to claim 1 , wherein the decarboxylation reaction is conducted at a temperature ranges from 100° C. to 150° C. 10. The method according to claim 9 , wherein the decarboxylation reaction is conducted at a temperature of 135° C. 11. The method according to claim 1 , the decarboxylation reaction is conducted at a pressure ranges 0.1 MPa to 0.5 MPa. 12. The method according to claim 11 , the decarboxylation reaction is conducted at a pressure of 0.2 MPa. 13. The method according to claim 1 , further comprising the step of recovering and purifying nicotinic acid.
Assignees
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Classifications
- C12P17/12Primary
containing a six-membered hetero ring · CPC title
in position 3 · CPC title
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression · CPC title
Vectors or expression systems specially adapted for E. coli · CPC title
Nitrogen as only ring hetero atom · CPC title
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- What does patent US9297030B2 cover?
- A method for the preparation of nicotinic acid, which includes the step of obtaining a culture solution containing quinolinic acid by incubating a microorganism having an ability to produce quinolinic acid, and the step of adding an acid to the culture solution and conducting a decarboxylation reaction.
- Who is the assignee on this patent?
- Kim So Young, Shin Yong Uk, Heo In Kyung, and 8 more
- What technology area does this patent fall under?
- Primary CPC classification C12P17/12. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 29 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).