Oxygen depletion devices and methods for removing oxygen from red blood cells

Patent metadata

Field	Value
Publication number	US-9296990-B2
Application number	US-201314038001-A
Country	US
Kind code	B2
Filing date	Sep 26, 2013
Priority date	Oct 12, 2009
Publication date	Mar 29, 2016
Grant date	Mar 29, 2016

Abstract

An oxygen depletion device. The device has a cartridge; a plurality of hollow fibers extending within the cartridge from an entrance to an exit thereof; an amount of an oxygen scavenger packed within the cartridge and contiguous to and in between the plurality of hollow fibers. The hollow fibers are adapted to receiving and conveying red blood cells. There is another embodiment of an oxygen depletion device and method for removing oxygen from red blood cells.

First claim

What is claimed:

1. A method for adding oxygen to red blood cells comprising: passing red blood cells through an oxygen addition device, wherein said device comprises:
a receptacle of a solid material having an inlet and an outlet receiving and expelling a gas; and
a plurality of hollow fibers extending within said receptacle from an entrance to an exit thereof, wherein said plurality of hollow fibers receive and convey said red blood cells, wherein said red blood cells are passaged within said hollow fibers.

2. The method of claim 1 , wherein said red blood cells entering said oxygen addition device are oxygen-depleted red blood cells.

3. The method of claim 1 , wherein said gas is pure oxygen.

4. The method of claim 1 , wherein said gas is air.

5. The method of claim 1 , wherein said plurality of hollow fibers are formed from an oxygen-permeable material selected from the group consisting of polyolefin, polytetrafluoroethylene, polyester, polyvinylidene fluoride (PVDF), and polysulfone.

6. The method of claim 1 , wherein said plurality of hollow fibers are formed from a hydrophobic polymer.

7. The method of claim 1 , wherein said plurality of hollow fibers are formed from an inorganic ceramic.

8. The method of claim 1 , wherein said plurality of hollow fibers are configured as a linear spiral, a longitudinal spiral, or a coil.

9. A method for preparing red blood cells for transfusion into a subject in need thereof, comprising: passing red blood cells through an oxygen addition device and transfusing re-oxygenated red blood cells to said subject, wherein said device comprises:
a receptacle of a solid material having an inlet and an outlet receiving and expelling a gas; and
a plurality of hollow fibers extending within said receptacle from an entrance to an exit thereof, wherein said plurality of hollow fibers receive and convey said red blood cells, wherein said red blood cells are passaged within said hollow fibers.

10. The method of claim 9 , wherein said subject is a patient with inadequate lung capacity to re-oxygenate transfused blood.

11. The method of claim 9 , wherein said subject is a patient with sickle cell anemia.

12. The method of claim 9 , wherein said red blood cells entering said oxygen addition device are oxygen-depleted red blood cells.

13. The method of claim 9 , wherein said gas is pure oxygen.

14. The method of claim 9 , wherein said gas is air.

15. The method of claim 9 , wherein said plurality of hollow fibers are formed from an oxygen-permeable material selected from the group consisting of polyolefin, polytetrafluoroethylene, polyester, polyvinylidene fluoride (PVDF), and polysulfone.

16. The method of claim 9 , wherein said plurality of hollow fibers are formed from a hydrophobic polymer.

17. The method of claim 9 , wherein said plurality of hollow fibers are formed from an inorganic ceramic.

18. The method of claim 9 , wherein said plurality of hollow fibers are configured as a linear spiral, a longitudinal spiral, or a coil.

Assignees

• New Health Sciences Inc
• Univ Pittsburgh—Of The Commonwealth System Of Higher Education
• Univ Pittsburgh

Inventors

• Federspiel William J
• Frankowski Brian J
• Yoshida Tatsuro
• Vernucci Paul J

Classifications

• A61P7/06

  Antianaemics · CPC title

• A61M2202/0429

  Red blood cells; Erythrocytes · CPC title

• A61M1/0272

  Apparatus for treatment of blood or blood constituents prior to or for conservation, e.g. freezing, drying or centrifuging · CPC title

• C12N5/0641 Primary

  Erythrocytes · CPC title

• A61M2202/0208

  Oxygen · CPC title