Crystalline forms of a Bruton's tyrosine kinase inhibitor

Patent metadata

Field	Value
Publication number	US-9296753-B2
Application number	US-201313908949-A
Country	US
Kind code	B2
Filing date	Jun 3, 2013
Priority date	Jun 4, 2012
Publication date	Mar 29, 2016
Grant date	Mar 29, 2016

Abstract

Described herein is the Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, including crystalline forms, solvates and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions that include the Btk inhibitor, as well as methods of using the Btk inhibitor, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

First claim

What is claimed is:

1. A crystalline Form A of 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one that has (a) an X-Ray powder diffraction (XRPD) pattern as shown in FIG. 1 and optionally at least one of the following properties:
(a) an X-Ray powder diffraction (XRPD) pattern as shown in FIG. 1 ;
(b) an X-ray powder diffraction (XRPD) pattern with characteristic peaks at 5.7±0.1° 2-Theta, 13.6±0.1° 2-Theta, 16.1±0.1° 2-Theta, 18.9±0.1° 2-Theta, 21.3±0.1° 2-Theta, and 21.6±0.1° 2-Theta;
(c) the same X-ray powder diffraction (XRPD) pattern post storage at 40° C. and 75% RH for at least a week;
(d) the same X-ray powder diffraction (XRPD) pattern post storage at 25° C. and 97% RH for at least a week;
(e) Infrared (IR) spectrum as the one set forth in FIG. 2 ;
(f) Infrared (IR) spectrum weak peaks at about 1584 cm −1 , about 1240 cm −1 , about 1147 cm −1 , about 1134 cm −1 , about 1099 cm −1 , and about 1067 cm −1 ;
(g) a DSC thermogram as the one set forth in FIG. 3 ;
(h) a thermo-gravimetric analysis (TGA) thermogram as the one set forth in FIG. 4 ;
(i) a DSC thermogram with an endotherm having an onset at about 154° C. and a peak at about 157° C. and an exotherm at about 159° C.;
(j) non-hygroscopicity;
(k) an observed aqueous solubility of about 0.013 mg/mL at about pH 8;
or
(l) combinations thereof.

2. The crystalline form of claim 1 , wherein the crystalline form has the same X-ray powder diffraction (XRPD) pattern post storage at 40° C. and 75% RH for at least a week.

3. The crystalline form of claim 1 , wherein the crystalline form has the same X-ray powder diffraction (XRPD) pattern post storage at 25° C. and 97% RH for at least a week.

4. The crystalline form of claim 1 , wherein the crystalline form has an Infrared (IR) spectrum as the one set forth in FIG. 2 .

5. The crystalline form of claim 1 , wherein the crystalline form has an Infrared (IR) spectrum weak peaks at about 1584 cm −1 , about 1240 cm −1 , about 1147 cm −1 , about 1134 cm −1 , about 1099 cm −1 , and about 1067 cm −1 .

6. The crystalline form of claim 1 , wherein the crystalline form has a melting temperature of about 155-156° C.

7. The crystalline form of claim 1 , wherein the crystalline form has a DSC thermogram as the one set forth in FIG. 3 .

8. The crystalline form of claim 1 , wherein the crystalline form has a thermo-gravimetric analysis (TGA) thermogram as the one set forth in FIG. 4 .

9. The crystalline form of claim 1 , wherein the crystalline form has a DSC thermogram with an endotherm having an onset at about 154° C. and a peak at about 157° C. and an exotherm at about 159° C.

10. The crystalline form of claim 1 , wherein the crystalline form is non-hygroscopic.

11. The crystalline form of claim 1 , wherein the crystalline form has an observed aqueous solubility of about 0.013 mg/mL at about pH 8.

12. The crystalline form of claim 1 , wherein the crystalline form that is characterized as having properties (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), and (k).

13. The crystalline form of claim 1 , wherein the crystalline form was obtained from ethyl acetate, isopropyl acetate, tetrahydrofuran, methyl isobutyl ketone (MIBK), methyl ethyl ketone (MEK), nitromethane, methanol, ethanol, acetonitrile, dioxane, methyl tert-butyl ether (MTBE), anisole, acetone, heptanes, a methanol/water or an acetone/heptane mixture.

14. The crystalline form of claim 1 , wherein the crystalline form is unsolvated.

15. The crystalline form of claim 1 , wherein the crystalline form is anhydrous.

16. A pharmaceutical formulation for oral administration comprising:
(a) 140 mgs of crystalline Form A of 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one that has an X-Ray powder diffraction (XRPD) pattern as shown in FIG. 1 ;
(b) 45.9 wt % of microcrystalline cellulose;
(c) 7.0 wt % of croscarmellose sodium;
(d) 4.2 wt % of sodium lauryl sulfate; and
(e) 0.5 wt % of magnesium stearate.

17. A crystalline Form A of 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one that has an X-ray powder diffraction (XRPD) pattern with characteristic peaks at 5.7±0.1 ° 2-Theta, 13.6±0.1° 2-Theta, 16.1±0.1° 2-Theta, 18.9±0.1 ° 2-Theta, 21.3±0.1° 2-Theta, and 21.6±0.1° 2-Theta; and at least one of the following properties:
(i) an X-Ray powder diffraction (XRPD) pattern as shown in FIG. 1 ;
(ii) the same X-ray powder diffraction (XRPD) pattern post storage at 40° C. and 75% RH for at least a week;
(iii) the same X-ray powder diffraction (XRPD) pattern post storage at 25° C. and 97% RH for at least a week;
(iv) Infrared (IR) spectrum as the one set forth in FIG. 2 ;
(v) Infrared (IR) spectrum weak peaks at about 1584 cm −1 , about 1240 cm −1 , about 1147 cm −1 , about 1134 cm −1 , about 1099 cm −1 , and about 1067 cm −1 ;
(vi) a DSC thermogram as the one set forth in FIG. 3 ;
(vii) a thermo-gravimetric analysis (TGA) thermogram as the one set forth in FIG. 4 ;
(viii) a DSC thermogram with an endotherm having an onset at about 154° C. and a peak at about 157° C. and an exotherm at about 159° C.;
(ix) non-hygroscopicity;
(x) an observed aqueous solubility of about 0.013 mg/mL at about pH 8; or
(xi) combinations thereof.

18. A pharmaceutical formulation for oral administration comprising: (a) 140 mgs of crystalline Form A of 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one that has an X-ray powder diffraction (XRPD) pattern with characteristic peaks at 5.7±0.1° 2-Theta, 13.6±0.1° 2-Theta, 16.1±0.1° 2-Theta, 18.9±0.1° 2-Theta, 21.3±0.1° 2-Theta, and 21.6±0.1° 2-Theta; (b) 45.9 wt % of microcrystalline cellulose; (c) 7.0 wt % of croscarmellose sodium; (d) 4.2 wt % of sodium lauryl sulfate; and (e) 0.5 wt % of magnesium stearate.

Assignees

• Pharmacyclics Llc

Inventors

• Smyth Mark
• Goldman Erick
• Wirth David D
• Purro Norbert

Classifications

• A61P37/00

  Drugs for immunological or allergic disorders · CPC title

• A61P35/02

  specific for leukemia · CPC title

• A61P35/00

  Antineoplastic agents · CPC title

• A61P39/00

  General protective or antinoxious agents · CPC title

• A61P37/06

  Immunosuppressants, e.g. drugs for graft rejection · CPC title