Azacyclic compounds

Patent metadata

Field	Value
Publication number	US-9296694-B2
Application number	US-201514628156-A
Country	US
Kind code	B2
Filing date	Feb 20, 2015
Priority date	Mar 6, 2000
Publication date	Mar 29, 2016
Grant date	Mar 29, 2016

Abstract

Compounds and methods are provided for the treatment of disease conditions in which modification of serotonergic receptor activity has a beneficial effect. In the method, an effective amount of a compound is adminstered to a patient in need of such treatment.

First claim

We claim:

1. A compound of formula (I)

or a pharmaceutically acceptable salt thereof, wherein
Z is

 in which
R is a hydrogen, a lower alkyl group, a cyclic organyl group, or a substituted or
unsubstituted aralkyl or heteroaralkyl group; and
n is 1;

X 1 is NH or N(lower alkyl) group;
X 2 is methylene;
Y 1 is methylene;
Y 2 is a bond, methylene, ethylene, or vinylene;
Ar 1 and Ar e are phenyl groups p-substituted with a substituent selected from the group consisting of lower alkyl, lower alkoxy and halogen; and
W is oxygen.

2. The compound or pharmaceutically acceptable salt of claim 1 , wherein R is a lower alkyl group.

3. The compound or pharmaceutically acceptable salt of claim 2 , wherein R is selected from the group consisting of methyl, ethyl, propyl, butyl, methylbutyl, cyclopropyl, cyclohexyl, iso-propyl and tert-butyl.

4. The compound or pharmaceutically acceptable salt of claim 2 , wherein aR 1 and Ar 2 are p-substituted with different substituents.

Assignees

• Acadia Pharm Inc

Inventors

• Andersson Carl-Magnus A
• Croston Glenn
• Hansen Eva Louise
• Uldam Allan Kjaersgaard

Classifications

• A61P9/00

  Drugs for disorders of the cardiovascular system · CPC title

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P7/02

  Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors · CPC title

• A61P9/10

  for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis · CPC title

• A61P9/08

  Vasodilators for multiple indications · CPC title