Molecular probe for imaging of pancreatic islets and use of the same
US-8980220-B2 · Mar 17, 2015 · US
Imaging beta cell mass
US9289516B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9289516-B2 |
| Application number | US-201114003959-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 27, 2011 |
| Priority date | Mar 9, 2011 |
| Publication date | Mar 22, 2016 |
| Grant date | Mar 22, 2016 |
How to read this patent
A practical reading order for non-experts. Skip the full description unless you need deep technical detail.
- Title
What the patent document calls the invention.
- Abstract
A short plain-language summary of the technical disclosure.
- Assignees and inventors
Who owns or filed the patent and who is credited as inventor.
- Key dates
Filing, priority, publication, and grant dates set the timeline.
- First independent claim
The legal scope of protection — read this for what is actually claimed.
- CPC / IPC classifications
Technology tags used to group this patent with similar filings.
- Citations and related patents
Prior art links and similar publications in this corpus.
Abstract
Official abstract text for this publication.
The present disclosure provides compositions and methods based on peptide-detectable agent conjugates that are useful for imaging beta cell mass.
First claim
Opening claim text (preview).
What is claimed is: 1. A composition comprising the peptide sequence SEQ ID NO:2, wherein the amino acid at position 12 is an unnatural amino acid, wherein the unnatural amino acid is (S)-2-amino-4-pentynoic acid. 2. A composition comprising the peptide sequence SEQ ID NO:3, wherein the amino acid at position 12 is cysteine. 3. The composition of claim 2 , wherein the cysteine is modified with a linker comprising a maleimide at a first end and a tetrazine at a second end. 4. The composition of claim 3 , wherein the cysteine has reacted with the maleimide via a 1,2-addition reaction. 5. The composition of claim 3 , wherein the tetrazine has reacted with a strained alkene attached to a detectable agent via an inverse electron demand Diels-Alder reaction. 6. The composition of claim 5 , wherein the strained alkene is trans-cyclooctene.
Assignees
Inventors
Classifications
Peptides, e.g. proteins {, carriers being peptides, polyamino acids, proteins} · CPC title
Methine dyes, e.g. cyanine dyes · CPC title
- A61K49/0056Primary
Peptides, proteins, polyamino acids · CPC title
Patent family
Related publications grouped by family.
External sources
Frequently asked questions
Answers are generated from the same data shown on this page.
- What does patent US9289516B2 cover?
- The present disclosure provides compositions and methods based on peptide-detectable agent conjugates that are useful for imaging beta cell mass.
- Who is the assignee on this patent?
- Weissleder Ralph, Reiner Thomas, Keliher Edmund J, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification A61K49/0056. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Mar 22 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).