Method for producing hematopoietic stem cells using pyrazole compounds
US-9212348-B2 · Dec 15, 2015 · US
Ex vivo and in vivo methods and related compositions for regenerating hematopoietic stem cell populations
US9284530B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9284530-B2 |
| Application number | US-201213342628-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 3, 2012 |
| Priority date | Sep 30, 2005 |
| Publication date | Mar 15, 2016 |
| Grant date | Mar 15, 2016 |
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Abstract
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Various embodiments provide methods and related compositions for increasing the population size of hematopoietic stem cells (HSCs) in patients that may benefit from reconstitution of stem cells and/or differentiated cells of the blood lineage. The present methods enable the production of HSCs ex vivo and in vivo by reducing latexin expression and/or latexin activity within HSC exposed to various antagonists. Inhibition of latexin expression and/or latexin activity by various antagonists can promote HSC proliferation and/or inhibit HSC apoptosis. Antagonists that can reduce latexin expression and/or latexin activity can be utilized to regenerate endogenous HSCs within patients affected with disorders, diseases, cancers, or therapies for such conditions, that result in the depletion or reduction in HSCs.
First claim
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We claim: 1. A method for reconstituting a recipient host with a population of hematopoietic stem cells (HSCs) generated in vivo, the method comprising: administering to the recipient host a pharmaceutical composition comprising an antagonist that reduces the expression and/or the activity of latexin, wherein the recipient host is affected with at least one condition selected from the group consisting of: a disease of the bone marrow, a cancer of the blood, a cancer of the bone mar…
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Chemistry & Metallurgy · mapped topic
- C12N5/0647Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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- What does patent US9284530B2 cover?
- Various embodiments provide methods and related compositions for increasing the population size of hematopoietic stem cells (HSCs) in patients that may benefit from reconstitution of stem cells and/or differentiated cells of the blood lineage. The present methods enable the production of HSCs ex vivo and in vivo by reducing latexin expression and/or latexin activity within HSC exposed to variou…
- Who is the assignee on this patent?
- Van Zant Gary, Liang Ying, Univ Kentucky Res Found
- What technology area does this patent fall under?
- Primary CPC classification C12N5/0647. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 15 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).