Method and system for collecting leukoreduced red blood cells

Patent metadata

Field	Value
Publication number	US-9284529-B2
Application number	US-201514625121-A
Country	US
Kind code	B2
Filing date	Feb 18, 2015
Priority date	Sep 10, 2012
Publication date	Mar 15, 2016
Grant date	Mar 15, 2016

Abstract

A method and system for collecting leukoreduced red blood cells employing a spinning membrane separator including a housing having an upper end region and a lower end region in an operating position with a red blood cell outlet in the upper end region of the housing and a whole blood inlet in the lower end region of the housing. The method and system provide for flowing additive solution into the whole blood inlet of the housing to prime the separator; flowing whole blood into the whole blood inlet of the housing; separating red blood cells from the whole blood; flowing separated red blood cells out of the red blood cell outlet of the housing; combining the separated red blood cells with additive solution; passing the separated red blood cells and additive solution combination through a leukoreduction filter; and collecting the filtered red blood cells and additive solution.

First claim

What is claimed:

1. A method for collecting leukoreduced red blood cells employing a spinning membrane separator including a membrane configured to spin about a generally vertically-oriented axis within a housing, the housing including an upper end region and a lower end region in an operating position and the separator including a red blood cell outlet in the upper end region of the housing and a whole blood inlet in the lower end region of the housing, the method comprising:
flowing additive solution from a first container into the whole blood inlet of the housing to prime the separator;
flowing whole blood into the whole blood inlet of the housing;
separating red blood cells from the whole blood;
flowing separated red blood cells out of the red blood cell outlet of the housing through a red blood cell flow path;
combining the separated red blood cells with additive solution from the first container in the red blood cell flow path;
passing the separated red blood cells and additive solution combination directly from the red blood cell flow path through a leukoreduction filter; and
collecting the filtered red blood cells and additive solution in a second container.

2. The method of claim 1 wherein the additive solution comprises a low-viscosity non-biological fluid.

3. The method of claim 1 wherein the additive solution comprises a preservative solution.

4. The method of claim 1 wherein flowing additive solution into the whole blood inlet comprises pumping additive solution into the inlet.

5. The method of claim 1 wherein combining red blood cells with additive solution comprises pumping additive solution into the red blood cell flow path.

6. The method of claim 1 wherein the separated red blood cells and additive solution combination is pumped through the leukoreduction filter.

Assignees

• Fenwal Inc

Inventors

• Kusters Benjamin
• Wegener Christopher
• Min Kyungyoon

Classifications

• A61M2202/0439

  White blood cells; Leucocytes · CPC title

• A61M1/3644

  Mode of operation · CPC title

• A61M1/3649

  using dialysate as priming or rinsing liquid · CPC title

• A61M1/265

  inducing Taylor vortices · CPC title

• B01D2313/08

  Flow guidance means within the module or the apparatus · CPC title