Agglomerated ion exchange particle bed and method

Patent metadata

Field	Value
Publication number	US-9283494-B2
Application number	US-22905705-A
Country	US
Kind code	B2
Filing date	Sep 16, 2005
Priority date	Sep 16, 2005
Publication date	Mar 15, 2016
Grant date	Mar 15, 2016

Abstract

A liquid chromatography agglomerated bed comprising component A comprising (a) substrate particles and polymer chains (e.g. a condensation polymer) bound to the substrate particles and projecting therefrom, and (b) component B comprising substrate particles having external surfaces of opposite charge to that of the charged polymer chains, components A and B being bound at least in part by electrostatic forces between the component A charged polymer chains and the component B external surfaces to form in composite an agglomerated bed of ion exchange particles packed in a chromatography column.

First claim

What is claimed is:

1. An agglomerated particle bed comprising ion exchange particles, said bed being suitable for use as chromatographic packing and comprising:
(a) component A comprising substrate particles and polymer chains of one charge, positive or negative, bound to said substrate particles, said component A polymer chains being formed by at least first and second condensation polymer reaction products of an amine and a polyfunctional compound, said first reaction product being attached to said component A substrate particles and comprising the reaction product of an amine and a polyfunctional compound, and said second reaction product being bound to said first reaction products, and
(b) component B comprising substrate particles having external surfaces of opposite charge to that of said charged polymer chains, at least some of said component A and component B being bound at least in part by electrostatic forces between said component A charged polymer chains and said component B external surfaces forming, in composite, an agglomerated bed of ion exchange particles; the ratio of particle diameters of component A and component B being between 0.2:1 and 5:1.

2. The bed of claim 1 in which said component B charged external surfaces comprise charged polymer chains of opposite charge to said component A polymer chains.

3. The bed of claim 1 in which said component A substrate particles are macroporous and said component A polymer chains project from the macropores of said particles.

4. The bed of claim 1 in which said polymer chains project from the surface of said component A substrate particles.

5. The bed of claim 1 in which said component A substrate particles have substantially uncharged cores to which said component A polymer chains are affixed.

6. The bed of claim 1 further comprising component C substrate particles substantially smaller than said component A substrate or component B substrate particles, and of opposite charge to said component B external surfaces, said component C particles being bound to said component B external surfaces at least in part by electrostatic forces.

7. The bed of claim 1 in which said component B substrate particles are entangled in said projecting component A polymer chains.

8. The bed of claim 1 in which the ratio of said component A substrate to said component B substrate particles is from about 1 to 99 to from about 99 to 1.

9. The bed of claim 1 in which said bed is disposed in a chromatography column.

10. A method of liquid chromatography comprising separating ionic species in a liquid sample stream by flowing the stream in an eluent through the chromatography column of claim 9 .

11. An agglomerated bed comprising ion exchange particles, said bed being suitable for use as chromatographic packing and comprising:
(a) component A comprising substrate particles and polymer chains of one charge, positive or negative, bound to said substrate particles, said component A polymer chains being formed by at least first and second condensation polymer reaction products of an amine and a polyfunctional compound, said first reaction product being attached to said component A substrate particles and comprising the reaction product of an amine and a polyfunctional compound, and said second reaction product being bound to said first reaction products, and
(b) component B comprising substrate particles having external surfaces of opposite charge to that of said charged polymer chains, at least some of said component A and component B being bound at least in part by electrostatic forces between said component A charged polymer chains and said component B external surfaces forming, in composite, an agglomerated bed of ion exchange particles; the diameters of component A and component B varying by no more than 400%.

Assignees

• Pohl Christopher A
• Saini Charanjit
• Dionex Corp

Inventors

• Pohl Christopher A
• Saini Charanjit

Classifications

• B01J41/20

  Anion exchangers for chromatographic processes · CPC title

• B01J20/3221

  the chemical bond being an ionic interaction · CPC title

• B01J39/26

  Cation exchangers for chromatographic processes · CPC title

• B01D15/361 Primary

  Ion-exchange · CPC title

• B01J47/016

  Modification or after-treatment of ion-exchangers · CPC title