Implantable drug delivery devices for genitourinary sites

Patent metadata

Field	Value
Publication number	US-9283361-B2
Application number	US-201113813745-A
Country	US
Kind code	B2
Filing date	Aug 3, 2011
Priority date	Aug 5, 2010
Publication date	Mar 15, 2016
Grant date	Mar 15, 2016

Abstract

Implantable drug delivery devices are provided lo have a deployment shape for implantation in the body and a retention shape for retention in the body. The device may have one or more elongated drug reservoirs containing a drug, mid the drug reservoir may be formed from a deformable material. In one case, a first filament is attached to the first end of the drug reservoir and second filament is attached to the second end of the drug reservoir, wherein a fastener is positioned about the first and second filaments to permit shortening and prevent lengthening of the filaments with reference to the ends of the daig reservoir, as a means for transforming the device from the implantation shape to the retention shape.

First claim

We claim:

1. An implantable drug delivery device, comprising:
a drug reservoir, the drug reservoir having an elongated shape, the drug reservoir formed from a deformable material;
a drug loaded in the drug reservoir;
a first filament attached to a first end of the drug reservoir;
a second filament attached to a second end of the drug reservoir; and
a fastener positioned about the first and second filaments, the fastener permitting shortening and preventing lengthening of the filaments with reference to the ends of the drug reservoir.

2. The implantable drug delivery device of claim 1 , wherein the fastener comprises a cinch nut.

3. The implantable drug delivery device of claim 1 , wherein the fastener is adjustable to enable the device to be deformed from a relatively linear deployment shape to a relatively circular retention shape.

4. An implantable drug delivery device comprising:
a plurality of drug reservoirs;
a drug loaded in the drug reservoirs;
a plurality of flexible joints joining the drug reservoirs together at their ends, at least one of the flexible joints having an opening;
a filament extending from one of the flexible joints through the opening; and
a fastener positioned on the filament, the fastener being movable through the opening upon engagement of the filament to lock the drug reservoirs in a retention shape.

5. The implantable drug delivery device of claim 4 , wherein the fastener comprises a locking bead.

6. An implantable drug delivery device comprising:
a bellows-shaped drug reservoir;
a drug loaded in the drug reservoir;
a braided basket positioned about the drug reservoir;
two filaments positioned between the drug reservoir and the braided basket, attached to both; and
a fastener associated with the filaments, wherein the device can be moved into a retention shape of increased width and reduced length by pulling the filaments through the fastener, causing the basket to expand outward.

7. A method of administering a drug to a patient in need thereof, comprising:
deploying the implantable drug delivery device of claim 1 into the patient; and
releasing from the deployed device one or more drugs into the patient.

8. The method of claim 7 , wherein the step of deploying an implantable drug delivery device comprises deploying the device through a deployment instrument into the patient's bladder.

9. A method of administering a drug to a patient in need thereof, comprising:
deploying the implantable drug delivery device of claim 4 into the patient; and
releasing from the deployed device one or more drugs into the patient.

10. The method of claim 9 , wherein the step of deploying an implantable drug delivery device comprises deploying the device through a deployment instrument into the patient's bladder.

11. A method of administering a drug to a patient in need thereof, comprising:
deploying the implantable drug delivery device of claim 6 into the patient; and
releasing from the deployed device one or more drugs into the patient.

12. The method of claim 11 , wherein the step of deploying an implantable drug delivery device comprises deploying the device through a deployment instrument into the patient's bladder.

Assignees

• Dicesare Paul
• Radziunas Jeffrey
• Barnes Andrew
• Britschock Eric
• Sutton David
• Taris Biomedical Llc

Inventors

• Dicesare Paul
• Radziunas Jeffrey
• Barnes Andrew
• Britschock Eric
• Sutton David

Classifications

• A61M31/002 Primary

  Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time (artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50) · CPC title

• A61M2210/1085

  Bladder · CPC title