Dispenser and method for entraining powder in an airflow

Patent metadata

Field	Value
Publication number	US-9283337-B2
Application number	US-80915508-A
Country	US
Kind code	B2
Filing date	Dec 18, 2008
Priority date	Dec 20, 2007
Publication date	Mar 15, 2016
Grant date	Mar 15, 2016

Abstract

The present disclosure relates to a method for entraining in an airflow a medicament powder contained in a cavity having a cavity opening. Large airflow vortices are provided, for instance, by use of an obstacle in a flow passage, The airflow with large vortices is arranged to by-pass the cavity opening, thereby generating an eddy in the cavity which contributes to entraining the powder in said airflow. The present disclosure also relates to a medical dispenser, for instance an inhaler, in which the method may be performed.

First claim

The invention claimed is:

1. A method for entraining in an airflow, flowing through a passageway having a longitudinal axis, a medicament powder contained in a cavity having a cavity opening in fluid communication with the passageway, wherein the passageway includes a lower surface region containing the cavity opening and an obstacle, which is fixed and rigid, located upstream of the cavity opening, and an upper surface region extending continuously parallel to the longitudinal axis from upstream of the obstacle to downstream of the cavity and located opposite the lower surface region, comprising:
providing an airflow to be passed generally parallel to the longitudinal axis between the upper surface region and the lower surface region and outside the cavity along the cavity opening, the provided airflow initially having a first flow pattern;
changing, upstream of the cavity opening, the first flow pattern into a second flow pattern having larger vortices than the first flow pattern; and
passing, along the cavity opening, the airflow having said second flow pattern, thereby generating an eddy in the cavity which contributes to entraining the medicament powder in said airflow to provide less than about 10% retention of, medicament powder within the cavity, wherein the cavity always remains stationary relative to the passageway.

2. The method of claim 1 , further including:
directing the airflow having said second flow pattern such that a main flow direction is substantially parallel with a plane coinciding with a rim defining the cavity opening.

3. The method as claimed in claim 2 , further including:
directing the airflow having said first flow pattern at an inclination relative to the plane coinciding with the rim defining the cavity opening; and
changing the first flow pattern into the second flow pattern before the airflow is directed substantially in parallel with said plane.

4. A medical dispenser, comprising:
a powder containing cavity;
a flow passage comprising a flat surface region, which is generally flat, located upstream of the cavity, wherein the powder containing cavity is fixedly and rigidly coupled to the flat surface region and the flat surface region comprises an opening from the flow passage into the powder containing cavity; and
an obstacle located in the flow passage upstream of the powder containing cavity and not extending into the powder containing cavity, wherein the obstacle is configured to cause an airflow to pass around and over the obstacle and the obstacle is fixedly and rigidly coupled to and extends from a flow passage-defining wall portion that is positioned upstream of and at an incline with respect to said flat surface region.

5. The method of claim 1 , wherein the eddy moves generally laterally within the cavity.

6. The method of claim 5 , wherein the eddy wobbles within the cavity.

7. The medical dispenser of claim 4 , wherein the opening has a leading edge, a trailing edge, and two diverging side edges.

8. The medical dispenser of claim 4 , wherein the obstacle has a longitudinal axis positioned at an angle relative to a longitudinal axis of the flow passage.

9. The medical dispenser of claim 4 , wherein the obstacle has a substantially triangular cross section.

10. The medical dispenser of claim 4 , wherein the flow passage includes a longitudinal axis, and the powder containing cavity and the obstacles are positioned along the longitudinal axis.

11. The medical dispenser of claim 4 , wherein the flow passage and the powder containing cavity both include side walls extending downstream that at least partially diverge in a downstream direction.

12. The medical dispenser of claim 4 , wherein the obstacle includes a cross section extending parallel to the flat surface region that is rectangular.

13. The medical dispenser of claim 4 , wherein the obstacle includes a top surface extending parallel to the flat surface region.

14. The medical dispenser of claim 13 , wherein the top surface is in a plane coincident with the flat surface region.

15. The medical dispenser of claim 4 , wherein the flow passage includes an upper surface that is located opposite to the flat surface region and that extends continuously and linearly from upstream of the obstacle to downstream of the powder containing cavity.

16. The medical dispenser of claim 4 , wherein the flow passage includes an edge extending laterally across the flow passage and separating the flow passage-defining wall portion from the flat surface region.

Assignees

• Lastow Orest
• Remmelgas Johan
• Briant John
• Astrazeneca Ab

Inventors

• Lastow Orest
• Remmelgas Johan
• Briant John

Classifications

• A61M15/0025

  with caps · CPC title

• A61M2202/064

  Powder · CPC title

• A61M2206/10

  Flow characteristics · CPC title

• A61M15/0065 Primary

  Inhalators with dosage or measuring devices (A61M15/0028 takes precedence; dosage devices incorporated in aerosol cans B65D83/52) · CPC title

• A61M15/0045 Primary

  using multiple prepacked dosages on a same carrier, e.g. blisters · CPC title