Targeted polymeric conjugates and uses thereof

Patent metadata

Field	Value
Publication number	US-9283279-B2
Application number	US-201214117043-A
Country	US
Kind code	B2
Filing date	May 10, 2012
Priority date	May 11, 2011
Publication date	Mar 15, 2016
Grant date	Mar 15, 2016

Abstract

Polymeric conjugates comprising a polymeric backbone having attached thereto a bone targeting moiety and a therapeutically active agent, wherein the bone targeting moiety is attached to one end of the polymeric backbone via a branching unit such that a molar ratio of the bone targeting moiety to the polymer is at least 2:1, are disclosed. Pharmaceutical compositions containing these conjugates and uses thereof in the treatment of bone related disorders are also disclosed.

First claim

What is claimed is:

1. A conjugate having the structure:

wherein n is an integer that ranges from 10 to 1000.

2. A conjugate having the structure:

wherein n is an integer that ranges from 10 to 1000,
wherein X is a lysine residue coupled to a labeling agent.

3. A pharmaceutical composition comprising, as an active ingredient, the conjugate of claim 1 and a pharmaceutically acceptable carrier.

4. The pharmaceutical composition of claim 3 , being packaged in a packaging material and identified in print, in or on said packaging material, for use in the treatment of a bone related disease or disorder.

5. A pharmaceutical composition comprising, as an active ingredient, the conjugate of claim 2 and a pharmaceutically acceptable carrier.

6. A method of treating a bone related disease or disorder in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of the conjugate of claim 1 .

7. A method of monitoring a bone related disease or disorder in a subject, the method comprising:
administering to the subject the conjugate of claim 2 ; and employing an imaging technique for monitoring a distribution of the conjugate within the body or a portion thereof.

8. The pharmaceutical composition of claim 5 , being packaged in a packaging material and identified in print, in or on said packaging material, for use in monitoring a bone related disease or disorder.

Assignees

• Satchi-Fainaro Ronit
• Pasut Gianfranco
• Univ Ramot
• Univ Padova

Inventors

• Satchi-Fainaro Ronit
• Pasut Gianfranco

Classifications

• A61K47/60

  the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol · CPC title

• A61K47/56

  the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule · CPC title

• A61K47/641

  Branched, dendritic or hypercomb peptides · CPC title

• A61K47/24 Primary

  containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids · CPC title

• A61P35/00

  Antineoplastic agents · CPC title