Pharmaceutical compositions containing carboxylated starch

Patent metadata

Field	Value
Publication number	US-9283246-B2
Application number	US-201213606403-A
Country	US
Kind code	B2
Filing date	Sep 7, 2012
Priority date	Sep 7, 2011
Publication date	Mar 15, 2016
Grant date	Mar 15, 2016

Abstract

The present invention relates to pharmaceutical compositions containing carboxylated starch derivatives as well a their use as osmotics in particular for use in the treatment of chronic renal failure by dialysis.

First claim

The invention claimed is:

1. A pharmaceutical or medical dialysis solution containing at least one carboxylated starch derivative of the general structure I

wherein X denotes either H or a glucose unit, n and m are integers greater than or equal to 1 and the degree of oxidation, based on the COOH radical, is between ≧0.0001 and ≦1.

2. The dialysis solution according to claim 1 , wherein the degree of oxidation is between ≧0.01 and ≦1.

3. The dialysis solution according to claim 1 , wherein the degree of oxidation is between 0.05 and 0.98.

4. The dialysis solution according to claim 1 , wherein a 7.5 wt % aqueous solution of the carboxylated starch has an osmolarity of ≧3 mOsm/L.

5. The dialysis solution according to claim 1 , for use in the treatment of chronic renal failure by dialysis, preferably hemodialysis or peritoneal dialysis.

6. A kit configured for preparing the dialysis solution according to claim 1 , comprising
a first component,
a second component, and
optionally one or more additional components,

wherein by mixing the first component with the second component and optionally with the additional component(s), said dialysis solution is obtained.

7. A solid composition suitable for preparing the dialysis solution according to claim 1 , wherein the dialysis solution is obtained by dissolving the solid composition in a solvent.

8. A method comprising dissolving in a solvent at least one carboxylated starch derivative of the general structure I

wherein X denotes either H or a glucose unit, n and m are integers greater than or equal to 1 and the degree of oxidation, based on the COOH radical, is between ≧0.0001 and ≦1,
for preparing a dialysis solution according to claim 1 .

9. A method comprising mixing together the components of a kit according to claim 6 for preparing a pharmaceutical or medical dialysis solution.

10. A method comprising dissolving in a solvent a solid composition according to claim 7 for preparing a pharmaceutical or medical dialysis solution.

Assignees

• Fenn Dominik
• Schweitzer Thomas
• Fresenius Medical Care De Gmbh

Inventors

• Fenn Dominik
• Schweitzer Thomas

Classifications

• A61P7/08

  Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock (artificial tears A61P27/04) · CPC title

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61K31/718

  Starch or degraded starch, e.g. amylose, amylopectin · CPC title

• A61P1/16

  for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics · CPC title

• A61K31/724 Primary

  Cyclodextrins · CPC title