Delivery systems for delivering functional compounds to substrates and processes of using the same

Patent metadata

Field	Value
Publication number	US-9283188-B2
Application number	US-53021006-A
Country	US
Kind code	B2
Filing date	Sep 8, 2006
Priority date	Sep 8, 2006
Publication date	Mar 15, 2016
Grant date	Mar 15, 2016

Abstract

Delivery systems for incorporating functional compounds into substrates for use in various consumer products are disclosed. Specifically, the delivery system includes a carrier component comprising an ultrasonically energized adsorbent and one or more functional compounds. The ultrasonically energized adsorbent can adsorb the desired functional compounds and bind the functional compounds to the surface of the substrate.

First claim

What is claimed is:

1. A process of delivering functional compounds to a substrate, the process comprising:
energizing an adsorbent with ultrasonic energy using an ultrasonic treatment system comprising an inlet end, an outlet end, and an ultrasonic waveguide assembly, wherein the ultrasonic waveguide assembly is a horn assembly comprising a horn member comprising two or more agitating members connected to the horn member and extending at least in part transversely outward from the outer surface of the horn member in longitudinally spaced relationship with each other, the agitating members and the horn member being constructed and arranged for dynamic motion of the agitating members relative to the horn member upon ultrasonic vibration of the horn member such to create a nodal region of the horn member; wherein the adsorbent is selected from the group consisting of alumina, silica, activated carbon, zeolites and combinations thereof;
wherein the ultrasonic energy is produced by the ultrasonic waveguide assembly that is ultrasonically excited at a frequency of from about 15,000 Hz to about 100,000 Hz;
introducing a fluid comprising at least one functional compound through the inlet end at a flow rate of from about 100 ml/min to about 20 L/min; wherein the at least one functional compound is selected from the group consisting of pharmaceuticals, xenobiotics, therapeutic agents, nutritional agents, anti-viral agents, anti-microbial agents, UV absorbers, signal agents, and combinations thereof; wherein the fluid is at a temperature of from about 20° C. to about 90° C. and has a pH of from about 2.0 to about 10.0;
adsorbing the at least one functional compound to the surface of the energized adsorbent to form a carrier component of a delivery system, wherein the adsorbing step is conducted for a period of from about 10 seconds to about 10 minutes;
removing the carrier component through the outlet end; wherein the pressure within the ultrasonic treatment system is from about 1 psi to about 10 psi; and
contacting the carrier component with a substrate; wherein the substrate is selected from the group consisting of a product comprising a polyolefin polymer, the skin of a human or animal, and tissue inside a body of a human or animal.

2. The process as set forth in claim 1 wherein the adsorbent is alumina, the alumina being in the form of a particle selected from the group consisting of alumina particles and alumina covered particles.

3. The process as set forth in claim 2 wherein the particles have a particle size of from about 5 nanometers to less than 500 microns.

4. The process as set forth in claim 1 wherein the ultrasonic energy is produced by the ultrasonic waveguide assembly that is ultrasonically excited at a frequency of from about 20,000 Hz to about 40,000 Hz.

5. The process as set forth in claim 1 wherein the horn member is an elongated cylindrical horn member.

6. The process as set forth in claim 1 wherein the ultrasonic treatment system is a continuous ultrasonic treatment system.

7. The process as set forth in claim 6 wherein the ultrasonic treatment system further comprises an ultrasonic treatment chamber enclosing the horn member.

8. The process as set forth in claim 1 wherein the adsorbing step takes place in a batch process.

9. The process as set forth in claim 1 wherein the adsorbing step is conducted for a period of from about 5 minutes to about 10 minutes.

10. The process as set forth in claim 1 wherein the substrate is a woven or non-woven material made from a polyolefin polymer.

11. The process as set forth in claim 10 further comprising pre-treating the substrate prior to contacting the carrier component with the substrate.

12. The process as set forth in claim 10 further comprising post-treating the substrate subsequent to contacting the carrier component with the substrate.

13. The process as set forth in claim 1 wherein the substrate is tissue inside of the body of a patient.

14. The process as set forth in claim 1 wherein the functional compound is selected from the group consisting of pharmaceuticals and signal agents.

15. The process as set forth in claim 1 wherein the functional compound is selected from the group consisting of hydrocortisone, tetracycline, salicylanilide, albofungin, an anthraquinone dye, baicalin hydrate, baicalein, daunorubicin, salicylamide, salacetamide, salsalate, ascorbic acid, aspartame, salicylaldehyde and a UV absorber.

Assignees

• Janssen Robert Allen
• Mccraw Jr Earl C
• Thompson Kimberlee Fay
• Macdonald John Gavin
• Ehlert Thomas David
• Mcnichols Patrick Sean
• Kimberly Clark Co

Inventors

• Janssen Robert Allen
• Mccraw Jr Earl C
• Thompson Kimberlee Fay
• Macdonald John Gavin
• Ehlert Thomas David
• Mcnichols Patrick Sean

Classifications

• A61K9/0014

  Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00) · CPC title

• A61K33/06

  Aluminium, calcium or magnesium; Compounds thereof {, e.g. clay} · CPC title

• A61K8/25

  Silicon; Compounds thereof · CPC title

• A61K9/143 Primary

  with inorganic compounds · CPC title

• A61K47/06

  Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite · CPC title