Methods and compositions for cancer treatment
US-2024424094-A1 · Dec 26, 2024 · US
CNS delivery of therapeutic agents
US9283181B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9283181-B2 |
| Application number | US-201113168961-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 25, 2011 |
| Priority date | Jun 25, 2010 |
| Publication date | Mar 15, 2016 |
| Grant date | Mar 15, 2016 |
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- Title
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Abstract
Official abstract text for this publication.
The present invention provides an effective and less invasive approach for direct delivery of therapeutic agents to the central nervous system (CNS). In some embodiments, the present invention provides methods including a step of administering intrathecally to a subject suffering from or susceptible to a lysosomal storage disease associated with reduced level or activity of a lysosomal enzyme, a composition comprising a replacement enzyme for the lysosomal enzyme.
First claim
Opening claim text (preview).
We claim: 1. A method of treating a lysosomal storage disease associated with reduced level or activity of a lysosomal enzyme comprising a step of: administering intrathecally to a subject in need of treatment, a composition comprising a replacement enzyme for the lysosomal enzyme at a concentration at or greater than about 5 mg/ml at a dose amount of at least 10 mg, wherein the composition comprises phosphate at a concentration of no greater than 50 mM. 2. The method of claim 1 , wherein the composition further comprises one or more of (i) a buffering agent, (ii) a surfactant, or (iii) a tonicifier. 3. The method of claim 1 , wherein the composition has a pH of approximately 3.0-8.0. 4. The method of claim 1 , wherein the composition is administered at a single dose volume of less than 5 mL. 5. The method of claim 1 , wherein the intrathecal administration of the composition does not result in substantial adverse effect in the subject. 6. The method of claim 1 , wherein the intrathecal administration of the composition does not result in adaptive T-cell mediated immune response.
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Classifications
Drugs for disorders of the cardiovascular system · CPC title
Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title
for treating abnormal movements, e.g. chorea, dyskinesia · CPC title
Otologicals · CPC title
Antiepileptics; Anticonvulsants · CPC title
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Frequently asked questions
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- What does patent US9283181B2 cover?
- The present invention provides an effective and less invasive approach for direct delivery of therapeutic agents to the central nervous system (CNS). In some embodiments, the present invention provides methods including a step of administering intrathecally to a subject suffering from or susceptible to a lysosomal storage disease associated with reduced level or activity of a lysosomal enzyme, …
- Who is the assignee on this patent?
- Calias Pericles, Pan Jing, Powell Jan, and 6 more
- What technology area does this patent fall under?
- Primary CPC classification A61K38/465. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Mar 15 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).