Fluorochrome material and method for using the same

Patent metadata

Field	Value
Publication number	US-9282923-B2
Application number	US-201113701157-A
Country	US
Kind code	B2
Filing date	May 12, 2011
Priority date	Jun 1, 2010
Publication date	Mar 15, 2016
Grant date	Mar 15, 2016

Abstract

It is an object of the present invention to extend the usefulness of an iron-salen complex. The present invention is a new fluorochrome material containing Chemical Formula (I) below. However, M is Fe, Cr, Mn, Co, Ni, Mo, Ru, Rh, Pd, W, Re, Os, Ir, Pt, Nd, Sm, Eu, or Gd.

First claim

The invention claimed is:

1. A method comprising:
administering to an individual a fluorochrome material containing a metal-salen complex represented by Chemical Formula (I);

N,N′-Bis(salicylidene)ethylenediamine metal,

wherein M is Fe, Cr, Mo, Ru, Rh, Pd, W, Re, Os, Ir, Pt, Nd, Sm, Eu, or Gd, and the metal-salen complex is in the form of a particle having a particle diameter in the range of 2 to 60 μm;
externally applying a magnetic field to the individual to guide the fluorochrome material to a target area;
applying external light to the target area, thereby causing the fluorochrome material in the target area to luminesce, with a peak luminous wavelength of the metal-salen complex represented by Chemical Formula (I) around 380 nm;
confirming luminescence in the target area visually; and
removing luminescent target area tissue.

2. The method according to claim 1 , wherein M in the metal-salen complex represented by Chemical Formula (I) is Fe.

3. The method according to claim 1 ,
wherein the particle diameter of the metal-salen complex represented by Chemical Formula (I) ranges from 9 to 12 μm.

4. The method according to claim 2 ,
wherein the particle diameter of the metal-salen complex represented by Chemical Formula (I) ranges from 9 to 12 μm.

Assignees

• Ishikawa Yoshihiro
• Eguchi Haruki
• Ihi Corp
• Yoshihiro Ishikawa

Inventors

• Ishikawa Yoshihiro
• Eguchi Haruki

Classifications

• Y10T428/2982

  Particulate matter [e.g., sphere, flake, etc.] · CPC title

• C09B57/10

  Metal complexes of organic compounds not being dyes in uncomplexed form · CPC title

• C09K2211/187

  of the iron group metals, i.e. Fe, Co or Ni · CPC title

• C09K11/06

  containing organic luminescent materials · CPC title

• C09K2211/1007

  Non-condensed systems · CPC title