C-Met Modulators and Methods of Use
US-2015376133-A1 · Dec 31, 2015 · US
Method for producing fine particles of aripiprazole anhydride crystals B
US9278934B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9278934-B2 |
| Application number | US-201214128305-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 29, 2012 |
| Priority date | Jun 29, 2011 |
| Publication date | Mar 8, 2016 |
| Grant date | Mar 8, 2016 |
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Abstract
Official abstract text for this publication.
The present invention provides a novel method for producing fine particles of aripiprazole anhydride crystals B. The method for producing fine particles of aripiprazole anhydride crystals B comprises the steps of: (1) heating and dissolving crude aripiprazole in a lower alcohol, and subsequently cooling the resulting mixture to precipitate crystals to obtain crystals of aripiprazole lower alcohol solvate; (2) subjecting the crystals of aripiprazole lower alcohol solvate to wet-milling in the form of a slurry containing the lower alcohol; and (3) subjecting the dispersion of the wet-milled crystals to solid-liquid separation to obtain the crystals, and heating the crystals.
First claim
Opening claim text (preview).
The invention claimed is: 1. A method for producing fine particles of aripiprazole anhydride crystals B, the method comprising the steps of: (a) heating and dissolving crude aripiprazole in a lower alcohol, and subsequently cooling the resulting mixture to precipitate crystals to obtain crystals of aripiprazole lower alcohol solvate; (b) subjecting the crystals of aripiprazole lower alcohol solvate to wet-milling in the form of a slurry containing the lower alcohol; and (c) subjecting the dispersion of the wet-milled crystals to solid-liquid separation to obtain the crystals, and heating the crystals. 2. The production method according to claim 1 , wherein the volume average particle size of the obtained fine particles of aripiprazole anhydride crystals B is less than 50 μm. 3. The production method according to claim 1 or 2 , wherein the lower alcohol is methanol or ethanol. 4. The production method according to claim 3 , wherein the lower alcohol is ethanol. 5. The production method according to claim 4 , wherein the lower alcohol substantially contains no water. 6. The production method according to claim 5 , wherein the water content in the lower alcohol is less than 10 vol %. 7. The production method according to claim 6 , wherein the volume average particle size of the wet-milled crystals in step (b) is less than 50 μm. 8. The production method according to claim 7 , wherein the volume average particle size of the wet-milled crystals in step (b) is 15 to 20 μm. 9. The production method according to claim 1 or 2 , wherein the heating temperature in step (c) is in the range near the boiling point of the lower alcohol to about 125° C. 10. The production method according to claim 1 or 2 , wherein the lower alcohol is ethanol, and the heating temperature in step (c) is in the range of about 78 to 125° C.
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Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia · CPC title
- C07D215/22Primary
attached in position 2 or 4 · CPC title
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- What does patent US9278934B2 cover?
- The present invention provides a novel method for producing fine particles of aripiprazole anhydride crystals B. The method for producing fine particles of aripiprazole anhydride crystals B comprises the steps of: (1) heating and dissolving crude aripiprazole in a lower alcohol, and subsequently cooling the resulting mixture to precipitate crystals to obtain crystals of aripiprazole lower alcoh…
- Who is the assignee on this patent?
- Bando Takuji, Yano Katsuhiko, Fukana Makoto, and 2 more
- What technology area does this patent fall under?
- Primary CPC classification C07D215/22. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 08 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).