Systems and devices for molecule sensing and method of manufacturing thereof

Patent metadata

Field	Value
Publication number	US-9274430-B2
Application number	US-201314051142-A
Country	US
Kind code	B2
Filing date	Oct 10, 2013
Priority date	Oct 10, 2012
Publication date	Mar 1, 2016
Grant date	Mar 1, 2016

Abstract

Embodiments of the disclosure are directed to a device for molecule sensing. In some embodiments, the device includes a first electrode separated from a second electrode by a dielectric layer. The first electrode comprises a large area electrode and the second electrode comprises a small area electrode. At least one opening (e.g., trench) cut or otherwise created into the dielectric layer exposes a tunnel junction therebetween whereby target molecules in solution can bind across the tunnel junction.

First claim

What is claimed is:

1. A device for detecting one or more target molecules comprising:
a first bottom electrode having a first thickness, the first electrode deposited on onto a solid supporting layer;
a dielectric layer substantially covering the first electrode;
a second top electrode having a second thickness, the second electrode being separated from the first electrode by the dielectric layer, wherein the surface area of the second electrode is less than the surface area of the first electrode; and
at least one trench cut or etched through at least the second electrode and dielectric layer such that at least the bottom of the opening exposes the first electrode, the trench configured to expose a tunnel junction between the electrodes to facilitate communication of one or more target molecules with the first and second electrodes.

2. The device according to claim 1 , wherein the second electrode comprises a wire.

3. The device according to claim 1 , further comprising at least one adhesion layer arranged beneath at least one of the first and second electrodes.

4. The device according to claim 3 , wherein the adhesion layer includes a thickness of about 0.01 nm to about 1 nm.

5. The device according to claim 1 , wherein the dielectric layer covers substantially all of the first electrode save for a contact area for the first electrode, the contact area configured for connection to a contact pad at the edge of the device.

6. The device of claim 1 , further comprising first molecules for forming a non-covalent bond with the one or more target molecules, wherein the electrodes are chemically functionalized with the first molecules.

7. The device of claim 1 , further comprising a passivating layer between about 20 nm and about 500 nm covering a substantial portion of the surface of the electrodes.

8. The device of claim 7 , further comprising an electrolyte, wherein the passivating layer is configured to separate the electrolyte from the surface area of the electrodes.

9. The device of claim 1 , further comprising a passivating layer substantially encapsulating the device, the layer being between about 20 nm and about 500 nm in thickness.

10. The device according to claim 8 , wherein the passivating layer includes at least one opening arranged to correspond to the at least one trench.

11. The device according to claim 10 , wherein the at least one opening includes a width between about 4 μm and about 16 μm, and a length of between about 14 μm and about 56 μm.

12. The device of claim 10 , wherein the depth of the trench is between about 10 nm to about 500 nm.

13. The device according to claim 10 , wherein the trench includes a substantially rectangular shape.

14. The device according to claim 1 , wherein the at least one trench comprises a plurality of trenches.

15. The device according to claim 14 , wherein the plurality of trenches comprise a first trench and a second trench, wherein a longitudinal axis of the first trench is at an angle to the longitudinal axis of the second trench.

16. The device of claim 1 , wherein the second electrode is arranged in a cross or “T” configuration relative to the first electrode so as to separate one or more junctions therebetween.

17. The device of claim 1 , wherein the at least one trench includes a width or diameter of between about 2.5 nm to about 3 nm.

18. The device according to claim 1 , wherein the second electrode is substantially smaller than the first electrode.

Assignees

• Univ Arizona
• Univ Arizona State

Inventors

• Gyarfas Brett
• Lindsay Stuart
• Pang Pei

Classifications

• G01N27/44791

  Microapparatus (sample containers with integrated microfluidic structures B01L3/5027) · CPC title

• G01N33/48721 Primary

  Investigating individual macromolecules, e.g. by translocation through nanopores (Coulter counters in general G01N15/12; fabrication methods for nanoscale apertures B81B1/00; sequencing of nucleic acids C12Q1/68) · CPC title

• C12Q1/6869

  Methods for sequencing · CPC title

• G03F7/20 Primary

  Exposure; Apparatus therefor (photographic printing apparatus for making copies G03B27/00) · CPC title