Instrument for cassette for sample preparation

Patent metadata

Field	Value
Publication number	US-9273344-B2
Application number	US-201414525976-A
Country	US
Kind code	B2
Filing date	Oct 28, 2014
Priority date	Dec 27, 2006
Publication date	Mar 1, 2016
Grant date	Mar 1, 2016

Abstract

A parallel processing system for processing samples is described. In one embodiment, the parallel processing system includes an instrument interface parallel controller to control a tray motor driving system, a close-loop heater control and detection system, a magnetic particle transfer system, a reagent release system, a reagent pre-mix pumping system and a wash buffer pumping system.

First claim

The invention claimed is:

1. An apparatus comprising:
a rack;
a linear drive shaft;
a plurality of gears;
first and second vertical linear bearings;
a plurality of valve key shafts disposed on a first side of the rack, each of said valve key shafts comprising a magnet at an end of said valve key shafts distal to the rack;
a linear motor coupled to the plurality of valve key shafts via the linear drive shaft and the plurality of gears, wherein the linear motor is positioned on either end of the rack;
a vertical engagement driving motor coupled to the rack, wherein:
the vertical engagement driving motor is configured to vertically position the rack, wherein said vertical engagement driving motor is coupled to the first and second vertical linear bearings; and
the linear motor is configured to horizontally position and rotate the plurality of magnets and the valve key shafts via the plurality of gears.

2. The apparatus of claim 1 further comprising a vertical position sensor coupled to the rack and the vertical engagement driving motor, wherein the vertical position sensor is configured to detect a position of the plurality of valve key shafts.

3. The apparatus of claim 1 further comprising a horizontal position sensor.

4. The apparatus of claim 1 further comprising:
a second linear drive shaft;
a second plurality of gears;
a plurality of second valve key shafts disposed on the first side of the rack, each of said second valve key shafts comprising a magnet at an end of each of said second valve key shafts distal to the rack;
a second linear motor coupled to the plurality of second valve key shafts via the second linear drive shaft and the second plurality of gears.

5. The apparatus of claim 4 wherein the linear motor is positioned at a first end of the rack and the second linear motor is positioned at a second end of the rack.

6. The apparatus of claim 4 further comprising a first driving gear rack coupled to the linear motor and comprising a second driving gear rack coupled to the second linear motor.

7. The apparatus of claim 6 wherein the first driving gear rack engages each valve shaft of the plurality of valve key shafts and wherein the second driving gear rack engages each valve shaft of the plurality of second valve key shafts.

8. The apparatus of claim 1 wherein the vertical engagement driving motor is positioned between the first end of the rack and the second end of the rack, and wherein the vertical engagement driving motor is positioned proximal to a second side of the rack that is opposed to the first side of the rack.

9. The apparatus of claim 1 wherein the plurality of gears comprises parallel gears.

10. The apparatus of claim 1 wherein the apparatus is contained within an instrument configured for parallel processing of one or more samples.

11. The apparatus of claim 10 wherein the instrument is configured to perform a protocol selected to prepare a sample of the one or more samples.

12. The apparatus of claim 11 wherein the instrument comprises a touch screen display configured to allow a user to select the protocol.

13. The apparatus of claim 10 wherein the instrument comprises a magazine having one or more cassettes.

14. The apparatus of claim 13 wherein each cassette of the one or more cassettes comprises a plurality of valves.

15. The apparatus of claim 14 wherein each valve of said plurality of valves is configured to receive the magnet at the end of one of the plurality of valve key shafts.

Assignees

• Luminex Corp

Inventors

• Yu Steve Jia Chang
• Ching Jesus
• Lee Phillip You Fai
• Hu David Hsiang

Classifications

• G01N35/08 Primary

  using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis · CPC title

• G01N35/026

  having blocks or racks of reaction cells or cuvettes · CPC title

• G01N2035/0415

  moving in two dimensions in a horizontal plane · CPC title

• G01N2035/00801

  Holders for sample carriers, e.g. trays, caroussel, racks · CPC title

• G01N2035/00544

  using fluid flow · CPC title