Antibiotic peptide and preparation method therefor and application therefor

Patent metadata

Field	Value
Publication number	US-9273095-B2
Application number	US-201214112064-A
Country	US
Kind code	B2
Filing date	Jan 17, 2012
Priority date	Apr 18, 2011
Publication date	Mar 1, 2016
Grant date	Mar 1, 2016

Abstract

Disclosed are an antibiotic peptide and the like, having an amino acid sequence of Ac-Phe-Lys-Lys-Leu-Lys-Lys-Leu-Phe-Ser-Lys-Leu-Trp-Asn-Trp-Lys-NH 2 (SEQ ID No:2). Also disclosed are a method of preparing the antibiotic peptide and the like, and the application thereof. The antibiotic peptide and the like synthesized by the solid phase synthetic technology according to the present invention can be used as a formulation against microbial infection and as alternate or adjuvant medicaments of antibiotics in the prior art.

First claim

The invention claimed is:

1. An antimicrobial peptide with the amino acid sequence of Ac-F-K-K-L-K-K-L-F-S-K-L-W-N-W-K-NH 2 (SEQ ID No. 1).

2. The antimicrobial peptide of claim 1 , wherein any one L in said amino acid sequence of antimicrobial peptide is substituted by I.

3. The antimicrobial peptide of claim 1 , wherein any one F in the amino acid sequence of said antimicrobial peptide is substituted by L.

4. The antimicrobial peptide of claim 1 , wherein any one W in the amino acid sequence of said antimicrobial peptide is substituted L.

5. The antimicrobial peptide of claim 1 , wherein said antimicrobial peptide comprises all L-enantiomers or all D-enantiomers.

6. A therapeutic composition for inhibiting a bacterial and/or fungal infection, wherein the therapeutic composition includes the antimicrobial peptide of claim 1 .

7. A therapeutic composition for inhibiting a bacterial and/or fungal infection, wherein the therapeutic composition includes the antimicrobial peptide of claim 5 .

8. A antibacterial agent for inhibiting a bacterial and/or fungal infection, wherein the antibacterial agent includes the therapeutic composition of claim 6 .

Assignees

• Chen Yuxin
• Chen Mingxia
• Huang Yibing
• Li Yang
• Wang Yong
• Qu Lili
• Wang Wenren
• Jiangsu Protelight Pharmaceutical & Biotechnology Co Ltd

Inventors

• Chen Yuxin
• Chen Mingxia
• Huang Yibing
• Li Yang
• Wang Yong
• Qu Lili
• Wang Wenren

Classifications

• C07K7/08 Primary

  having 12 to 20 amino acids (gastrins C07K14/595; somatostatins C07K14/655; melanotropins C07K14/68) · CPC title

• A61K38/00

  Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00) · CPC title

• C07K14/4723

  Cationic antimicrobial peptides, e.g. defensins · CPC title

• A61P31/00

  Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics · CPC title