Methods for treating combined radiation and thermal injury

Patent metadata

Field	Value
Publication number	US-9272013-B2
Application number	US-201113637038-A
Country	US
Kind code	B2
Filing date	Mar 28, 2011
Priority date	Mar 26, 2010
Publication date	Mar 1, 2016
Grant date	Mar 1, 2016

Abstract

The present invention provides methods for treating a subject that has suffered combined exposure to total body ionizing irradiation and burns by administering a peptide of at least 5 amino acids of a peptide of SEQ ID NO:1 (Asp-Arg-Nle-Tyr-Ile-His-Pro), or a pharmaceutical salt thereof in an amount effective to treat the radiation effects and/or the burn.

First claim

We claim:

1. A method for improving survival in a subject that has suffered combined (i) exposure to total body ionizing irradiation of at least 0.2 Gy, and (ii) second degree burns over at least 7% of the subject's total body surface area, comprising administering to the subject an amount effective to treat the radiation effects and the burn of a peptide consisting of the peptide of SEQ ID NO:1 (Asp-Arg-Nle-Tyr-Ile-His-Pro), or a pharmaceutical salt thereof, wherein the method improves survival in the subject compared to control.

2. The method of claim 1 , wherein the method results in accelerated burn healing compared to control.

3. The method of claim 1 , wherein the subject has suffered second degree burns to one or more of the trunk, back, head, arm, or leg.

4. The method of claim 1 , wherein the subject has been exposed to total body ionizing irradiation of between 0.2 Gy and 10 Gy.

5. The method of claim 1 , wherein the subject has been exposed to total body ionizing irradiation of between 1 Gy and 10 Gy.

6. The method of claim 1 , wherein the subject has been exposed to total body ionizing irradiation of between 2 Gy and 10 Gy.

7. The method of claim 1 , wherein the subject has suffered cumulative exposure to total body ionizing irradiation of at least 20 cGy.

8. The method of claim 1 , wherein the total body ionizing radiation is selected from the group consisting of beta-irradiation, gamma-irradiation, and X-ray.

9. The method of claim 1 , wherein the total body ionizing irradiation is caused by exposure to a radiation source selected from the group consisting of nuclear weapons, nuclear power facilities, nuclear powered vehicles, and environment contaminated by radioactive materials.

10. The method of claim 1 , wherein the peptide is administered within three days of total body ionizing irradiation exposure.

11. The method of claim 1 , wherein the peptide is administered topically.

Assignees

• Rodgers Kathleen E
• Dizerega Gere S
• Univ Southern California

Inventors

• Rodgers Kathleen E
• Dizerega Gere S

Classifications

• A61K38/08 Primary

  Peptides having 5 to 11 amino acids {(A61K38/043 - A61K38/046 take precedence)} · CPC title

• A61P39/06

  Free radical scavengers or antioxidants · CPC title

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61K38/085 Primary

  Angiotensins · CPC title

• A61P17/02

  for treating wounds, ulcers, burns, scars, keloids, or the like · CPC title