Placental tissue grafts

Patent metadata

Field	Value
Publication number	US-9272005-B2
Application number	US-201514642535-A
Country	US
Kind code	B2
Filing date	Mar 9, 2015
Priority date	Aug 17, 2006
Publication date	Mar 1, 2016
Grant date	Mar 1, 2016

Abstract

A method for preparing placenta membrane tissue grafts for medical use, includes obtaining a placenta from a subject, cleaning the placenta, separating the chorion tissue from the amniotic membrane, mounting a selected layer of either the chorion tissue or the amniotic membrane onto a drying fixture, dehydrating the selected layer on the drying fixture, and cutting the selected layer into a plurality of tissue grafts. Preferably, the drying fixture includes grooves or raised edges that define the outer contours of each desired tissue graft, after they are cut, and further includes raised or indented logos that emboss the middle area of the tissue grafts during dehydration and that enables an end user to distinguish the top from the bottom side of the graft. The grafts are comprised of single layers of amnion or chorion, multiple layers of amnion or chorion, or multiple layers of a combination of amnion and chorion.

First claim

What is claimed is:

1. A sealed package comprising:
a sterile dehydrated placental tissue graft having a front side and a back side, wherein the placental tissue graft has at least one label on a portion thereof which visually distinguishes the front side from the back side of the graft and wherein said label is formed or configured by the dehydrated placental tissue; and
a sealable packaging element,
wherein the sealable packaging element is sealed to contain the sterile dehydrated placental tissue graft.

2. The package of claim 1 , wherein the tissue graft comprises amnion.

3. The package of claim 1 , wherein the tissue graft comprises chorion.

4. The package of claim 1 , wherein the tissue graft comprises amnion and chorion.

5. The package of claim 1 , wherein the at least one label is an embossment.

6. The package of claim 1 , wherein the at least one label is a logo, a design, a name, or text.

7. A sealed package comprising:
a sterile dehydrated placental tissue graft having a front side and back side, wherein the placental tissue graft has at least one configuration on a portion thereof which visually distinguishes the front side from the back side of the graft and wherein said label is formed or configured by the dehydrated placental tissue, and further wherein said tissue graft is a dehydrated, laminated graft containing two or more layers wherein said layers are selected from amnion and chorion provided that at least one of said layers is an amnion layer which retains its fibroblast layer and further provided that the layers are laminated to each other; and
a sealable packaging element,
wherein the sealable packaging element is sealed to contain the sterile dehydrated placental tissue graft.

8. The package of claim 7 , wherein the fibroblast layer of said amnion layer is laminated to an amnion or chorion layer.

Assignees

• Mimedx Group Inc

Inventors

• Daniel John

Classifications

• A61L27/3604 Primary

  characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel · CPC title

• A61L2300/60

  characterised by a special physical form · CPC title

• A61L27/3691

  characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation · CPC title

• A61L27/3683

  subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment · CPC title

• A61L27/58

  Materials at least partially resorbable by the body · CPC title