Oral compositions containing microaggregates

Patent metadata

Field	Value
Publication number	US-9271906-B2
Application number	US-201013884030-A
Country	US
Kind code	B2
Filing date	Nov 8, 2010
Priority date	Nov 8, 2010
Publication date	Mar 1, 2016
Grant date	Mar 1, 2016

Abstract

The invention relates to a composite and oral care compositions for use in the mouth to retard the accumulation of dental plaque and/or calculus. The composite is a microaggregate comprising polymer coated, surfactant stabilized particles of a substantially insoluble metal, metal salt or metal oxide, for example zinc oxide. Also methods for retarding the accumulation of dental plaque and/or calculus are provided.

First claim

What is claimed is:

1. A composite comprising microaggregates of polymer coated, nonionic surfactant stabilized particles of a substantially insoluble metal, metal salt or metal oxide, wherein the polymer is a water-soluble polymer or blend of water soluble polymers;
wherein the microaggregates average from 5 microns to 50 microns in major dimension;
wherein the non-ionic surfactant is selected from the group consisting of polyoxyethylene-sorbitan-fatty acyl ester, a polyoxyethylene-sorbitan-fatty ether, a polyhydroxyethylene-fatty monoacyl ester, a polyhydroxyethylene-fatty diacyl ester, and a polyhydroxyethylene-fatty ether; and
wherein the substantially insoluble metal, metal salt or metal oxide is selected from the group consisting of: zinc oxide, tin dioxide, calcium fluoride, titanium dioxide, and mixtures thereof.

2. The composite of claim 1 , wherein the polymer comprises hydroxypropylmethylcellulose.

3. The composite of claim 2 wherein the surfactant comprises polysorbate 80.

4. The composite of claim 1 , wherein the microaggregates are formed by spray drying a mixture comprising zinc oxide particles, surfactant and water-soluble polymer.

5. The composite of claim 1 , wherein the microaggregates comprise zinc oxide particles coated with a cellulose ether polymer, are generally spherical in shape, and average 20 microns in major dimension.

6. An oral care composition comprising a plurality of composites according to claim 1 .

7. The composition of claim 6 , wherein the composition is a toothpaste.

8. A method for retarding the accumulation of dental plaque and/or calculus comprising contacting oral surfaces with a plurality of composites according to claim 1 .

9. A method of making a composite comprising microaggregates of polymer coated, nonionic surfactant stabilized particles of a substantially insoluble metal, metal salt or metal oxide, wherein the polymer is a water-soluble polymer or blend of water soluble polymers according to claim 1 , comprising
mixing a coating polymer and a substantially insoluble metal, metal salt or metal oxide and a surfactant, optionally together with a nonpolymer carrier and/or an antifoaming agent, in a suitable solvent or carrier,
spray-drying the mixture; and
recovering the composite thus obtained,
wherein the polymer is a water-soluble polymer or blend of water soluble polymers;
wherein the microaggregates average from 5 microns to 50 microns in major dimension;
wherein the non-ionic surfactant is selected from the group consisting of polyoxyethylene-sorbitan-fatty acyl ester, a polyoxyethylene-sorbitan-fatty ether, a polyhydroxyethylene-fatty monoacyl ester, a polyhydroxyethylene-fatty diacyl ester, and a polyhydroxyethylene-fatty ether; and
wherein the substantially insoluble metal, metal salt or metal oxide is selected from the group consisting of: zinc oxide, tin dioxide, calcium fluoride, titanium dioxide, and mixtures thereof.

10. The composite of claim 3 , wherein the microaggregates are formed by spray drying a mixture comprising zinc oxide particles, surfactant and water-soluble polymer.

11. The composite of claim 10 , wherein the microaggregates comprise zinc oxide particles coated with a cellulose ether polymer, are generally spherical in shape, and average 20 microns in major dimension.

12. The composite of claim 1 , wherein the substantially insoluble metal, metal salt or metal oxide is zinc oxide.

13. The composite of claim 12 , wherein the surfactant is polysorbate 80.

Assignees

• Miller Steven
• Xu Guofeng
• Fei Lin
• Yang Ying
• Colgate Palmolive Co

Inventors

• Miller Steven
• Xu Guofeng
• Fei Lin
• Yang Ying

Classifications

• A61K8/27 Primary

  Zinc; Compounds thereof · CPC title

• A61K8/86

  Polyethers · CPC title

• A61K8/4993

  Derivatives containing from 2 to 10 oxyalkylene groups · CPC title

• A61K8/11 Primary

  Encapsulated compositions · CPC title

• A61K2800/412

  Microsized, i.e. having sizes between 0.1 and 100 microns · CPC title