2-hydroxyarylamide derivative or pharmaceutically acceptable salt thereof, preparation method thereof, and pharmaceutical composition for preventing or treating cancer containing same as active ingredient

Patent metadata

Field	Value
Publication number	US-9266872-B2
Application number	US-201414256808-A
Country	US
Kind code	B2
Filing date	Apr 18, 2014
Priority date	Oct 21, 2011
Publication date	Feb 23, 2016
Grant date	Feb 23, 2016

Abstract

The present invention relates to a 2-hydroxyarylamide derivative or a pharmaceutically acceptable salt thereof, a preparation method thereof, and a pharmaceutical composition for preventing or treating cancer comprising the same as an active ingredient. The 2-hydroxyarylamide derivative prepared by the present invention is excellent in the inhibition of the activity of TMPRSS4 serine protease and the suppression of the infiltration of TMPRSS4-expressed cancer cells, and thus can be useful as a composition for preventing or treating cancer by inhibiting TMPRSS4 over-expressed in cancer cells, particularly, colorectal cancer, lung cancer, breast cancer, prostate cancer, ovarian cancer, pancreatic cancer, or stomach cancer cells.

First claim

What is claimed is:

1. A method for inhibiting colorectal cancer metastasis comprising: administrating a pharmaceutically effective dose of a 2-hydroxyarylamide derivative or a pharmaceutically acceptable salt thereof, wherein the 2-hydroxyarylamide derivative is selected from the group consisting of:
(6) 5-chloro-2-hydroxy-N-(3-methoxy-5-(trifluoromethyl)phenyl)benzamide;
(19) 5-chloro-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxybenzamide;
(25) 5-chloro-2-hydroxy-N-quinoline-3-yl-benzamide;
(27) 5-chloro-N-(2-chloro-4-cyano-phenyl)-2-hydroxy-benzamide;
(28) 5-chloro-2-hydroxy-N-(5-trifluoromethyl-[1,3,4]thiadiazole-2-yl)-benzamide;
(32) 5-chloro-N-(4-chloro-3-(trifluoromethyl)phenyl)-2-hydroxybenzamide;
(36) 5-chloro-2-hydroxy-N-(2-nitro-4-trifluoromethyl-phenyl)-benzamide;
(37) 5-chloro-N-(5-cyano-pyridine-2-yl)-2-hydroxy-benzamide; and
(53) 5-chloro-2-hydroxy-N-(4-phenylthiazole-2-yl)benzamide;

wherein the 2-hydroxyarylamide derivative or a pharmaceutically acceptable salt thereof inhibits the activity of TMPRSS4 (transmembrane protease serine-4).

2. The method of claim 1 , wherein the 2-hydroxyarylamide derivative or a pharmaceutically acceptable salt thereof is administered orally or parenterally.

Assignees

• Korea Res Inst Of Bioscience

Inventors

• Kim Semi
• Lee Ill Young
• Min Hye-Jin
• Nam Eun-Hee
• Kim Pilho
• Yun Chang Soo
• Ko Dong Joon

Classifications

• A61K31/4709

  Non-condensed quinolines and containing further heterocyclic rings · CPC title

• A61K31/428

  condensed with carbocyclic rings · CPC title

• A61K31/426

  1,3-Thiazoles · CPC title

• C07D213/82

  in position 3 · CPC title

• C07D277/82

  Nitrogen atoms · CPC title