Devices, systems and methods for carbon dioxide angiography

Patent metadata

Field	Value
Publication number	US-9265877-B2
Application number	US-201313756798-A
Country	US
Kind code	B2
Filing date	Feb 1, 2013
Priority date	Feb 3, 2012
Publication date	Feb 23, 2016
Grant date	Feb 23, 2016

Abstract

Disclosed herein are various embodiments of devices, systems and methods for the delivery of carbon dioxide (CO 2 ) as a contrast agent for angiography. The CO 2 delivery device can include a syringe and a shuttle valve assembly in fluid communication with the syringe, such that the shuttle valve can be disposed in a first position to pressurize the syringe with CO 2 , and a second position to deliver a bolus of CO 2 to a subject.

First claim

The invention claimed is:

1. A CO 2 delivery device, comprising:
a syringe comprising a chamber; and
a shuttle valve assembly in fluid communication with the chamber of the syringe, the shuttle valve assembly comprising:
a valve block comprising a first opening;
a valve base comprising a first port and a second port;
a plurality of sealing members disposed between the valve block and the valve base; and
a biasing member biased against the valve block,

wherein when the CO 2 deliver device is in a first position the first opening is substantially aligned with the first port such that the first port and the chamber are in fluid communication and the second port is isolated between a first sealing member and a second sealing member such that the second port is not in fluid communication with the chamber, and wherein the biasing member biases the valve block into the first position which permits pressurization of the chamber with CO 2 gas;
wherein when the CO 2 deliver device is in a second position the first opening is substantially aligned with the second port such that the second port and the chamber are in fluid communication and the first port is isolated between a third sealing member and a fourth sealing member such that the first port is not in fluid communication with the chamber, and wherein when a force is applied against the biasing member, the valve block is disposed into the second position which permits delivery of a bolus of pressurized CO 2 as from the chamber to a patient.

2. The CO 2 delivery device of claim 1 , wherein the first position is independent from the second position.

3. The CO 2 delivery device of claim 1 , wherein the syringe further comprises a threaded plunger, and wherein the syringe is configured to receive a threaded plunger.

4. The CO 2 delivery device of claim 1 , further comprising:
a CO 2 cartridge,
wherein the CO 2 cartridge is directly coupled to the first port.

5. The CO 2 delivery device of claim 1 , wherein each of the plurality of sealing members comprises an o-ring.

6. A CO 2 delivery device, comprising:
a syringe, comprising
a chamber; and
a plunger; and

a shuttle valve assembly, comprising
a valve block having at least one opening;
a valve base having a first port and a second port;
a plurality of sealing members disposed between the valve block and the valve base; and
a biasing member biased against the valve block;

wherein when the CO 2 deliver device is in a first position the opening is substantially aligned with the first port such that the first port and the chamber are in fluid communication and the second port is isolated between a first sealing member and a second sealing member such that the second port is closed when the CO 2 delivery device is in a first position,
wherein when the CO 2 deliver device is in a second position the opening is substantially aligned with the second port such that the second port and the chamber are in fluid communication and the first port is isolated between a third sealing member and a fourth sealing member such that the first portion is closed when the CO 2 delivery device is in a second position, wherein the first position is independent from the second position, and wherein when a force is applied against the biasing member, the valve block is disposed into the second position which permits delivery of a bolus of pressurized CO 2 gas from the chamber to a patient.

7. The CO 2 delivery device of claim 6 , wherein the biasing member is configured to maintain the CO 2 delivery device in the first position absent outside force from a practitioner.

8. The CO 2 delivery device of claim 7 , wherein the CO 2 delivery device is disposed in the second position when a force is applied against the biasing member.

9. The CO 2 delivery device of claim 6 , further comprising:
a pressure regulator; and
a CO 2 cartridge,

wherein the CO 2 cartridge is coupled to the pressure regulator, and
wherein the pressure regulator is coupled to the first port.

10. The CO 2 delivery device of claim 9 , wherein the biasing member is configured to maintain the CO 2 delivery device in the first position such that the chamber is in fluid communication with the CO 2 cartridge.

11. The CO 2 delivery device of claim 10 , wherein the CO 2 delivery device is disposed in the second position when a force is applied against the biasing member such that the chamber is in fluid communication with the second port for delivery of a bolus of CO 2 to a patient.

12. The CO 2 delivery device of claim 6 , further comprising a CO 2 cartridge, wherein the CO 2 cartridge is coupled to the second port and the biasing member is configured to maintain the shuttle valve assembly in the first position, such that the chamber is in fluid communication with the first port, and wherein the CO 2 delivery device is disposed in the second position when a force is applied against the biasing member such that the chamber is in fluid communication with the CO 2 cartridge.

13. A system for introducing CO 2 as a contrast agent to a subject, the system comprising:
a CO 2 source; and
the CO 2 delivery device of claim 1 ,
wherein the CO 2 source is coupled to the CO 2 delivery device, and
wherein the CO 2 delivery device is configured to be coupled to the subject.

14. The system of claim 13 , the system further comprising a pressure regulator.

15. The system of claim 14 , the system further comprising a gas sensor.

16. The system of claim 15 , the system further comprising a filter.

17. The system of claim 16 , further comprising at least two tubing lines, wherein the CO 2 source is coupled to the CO 2 delivery device with at least one of the at least two tubing lines, and wherein the CO 2 delivery device is configured to be coupled to the subject with at least another of the at least two tubing lines.

18. A method for delivering CO 2 as a contrast agent to a subject, the method comprising:
coupling a CO 2 source at above atmospheric pressure to a CO 2 delivery device, wherein the CO 2 delivery device comprises:
a syringe; and
a shuttle valve assembly in fluid communication with a chamber of the syringe, the shuttle valve assembly comprising:
a valve block comprising an opening;
a valve base comprising a first port and a second port;
a plurality of sealing members disposed between the valve block and the valve base; and
a biasing member biased against the valve block,

wherein the CO 2 delivery device is in fluid communication with and receives pressurized CO 2 from the CO 2 source in a first position, wherein when the CO 2 delivery device is in the first position the opening of the valve block is substantially aligned with the first port of the valve base such that the first port and the chamber are in fluid communication and the second port of the valve base is isolated between a first sealing member and a second sealing member such that the second port is not in fluid communication with the chamber, and wherein the biasing member biases the valve block into the first position which permits pressurization of the chamber with CO 2 gas;

coupling the CO 2 delivery device to the subject;
actuating the CO 2 delivery device from the first position to a second position against the biasing force which delivers a bolus of CO 2 from the CO 2 delivery device to the subject, wherein when the CO 2 deliver device is in the second position the opening is substantially aligned with the second port of the valve base such that the seco

Assignees

• Merit Medical Systems Inc

Inventors

• Mcarthur Gregory R
• Stevens Brian
• Padilla William

Classifications

• A61M5/31551

  including axial movement of dose setting member · CPC title

• A61B6/481

  involving the use of contrast agents · CPC title

• A61M5/178

  Syringes · CPC title

• A61M2039/224

  of the slide-valve type · CPC title

• A61B6/504

  for diagnosis of blood vessels, e.g. by angiography · CPC title