Device and method for measuring a blood constituent in blood for an extracorporeal blood treating device

Patent metadata

Field	Value
Publication number	US-9265872-B2
Application number	US-201013263450-A
Country	US
Kind code	B2
Filing date	Apr 8, 2010
Priority date	Apr 11, 2009
Publication date	Feb 23, 2016
Grant date	Feb 23, 2016

Abstract

The invention relates to a device and a method for measuring a blood constituent in blood for an extracorporeal blood treatment device, comprising a dialyzer or a filter, and a hose line system comprising hose lines that are pervious to electromagnetic radiation. The kinetics of a liquid flowing at a measuring site in one of the hose lines of the hose line system is varied by varying the flow properties of the liquid in the hose line at the measuring site, particularly by stopping a blood pump arranged in the hose line and/or by closing a shut-off member in the hose line. The invention analyzes the intensity of the light entering the hose line at the measuring site and the light exiting the hose line at the measuring site.

First claim

What is claimed is:

1. A system for measuring a blood constituent in blood for an extra-corporeal blood treating apparatus, said extra-corporeal apparatus including a system of flexible lines, said flexible lines being substantially transmissive of electromagnetic radiation, wherein the system comprises:
a measuring set-up comprising:
an emitter configured to emit electromagnetic radiation which enters one of the flexible lines at a point of measurement, and
a receiver configured to receive electromagnetic radiation which emerges from the flexible line at the point of measurement,
wherein the measuring set-up is configured to supply measurement data to an analyzing unit, wherein the measurement data is characteristic of the intensity of the electromagnetic radiation which enters the flexible line at the point of measurement and which emerges from the flexible line at the point of measurement;

a blood pump arranged in one of the flexible lines and configured to pump blood;
a shut-off member arranged in one of the flexible lines; and
a control and computing unit configured to operate the blood pump and the shut-off member, wherein the control and computing unit is configured to stop the blood pump for a preset interval of time and, when the blood pump is stopped, the shut-off member is at least partly closed and then opened, to change the hydrodynamic behavior of the fluid flowing in one of the flexible lines at the point of measurement,
wherein the analyzing unit is configured to analyze measurement data obtained during the change in hydrodynamic behavior, and is configured to determine the concentration of the blood constituent from the measurement data obtained during the change in hydrodynamic behavior.

2. The system according to claim 1 , wherein the emitter is configured to emit electromagnetic radiation of a first wavelength and a second wavelength, said first wavelength and said second wavelength being different from one another.

3. The system according to claim 1 , wherein the emitter is configured to emit electromagnetic radiation in different directions which are orthogonal to one another.

4. The system according to claim 1 , wherein the receiver is configured to receive electromagnetic radiation from different directions which are orthogonal to one another.

5. The system according to claim 1 , wherein the electromagnetic radiation comprises light of a wavelength of between 385 nm and 950 nm.

6. The system according to claim 1 , wherein the blood constituent is glucose.

7. An apparatus for extra-corporeal blood treatment comprising:
a dialyzer or a filter divided by a semi-permeable membrane into a first chamber and a second chamber;
a system of flexible lines, said flexible lines being transmissive of electromagnetic radiation; and
a system for measuring a blood constituent in blood for an extra-corporeal blood treating apparatus, wherein the system comprises:
a measuring set-up comprising:
an emitter configured to emit electromagnetic radiation which enters one of the flexible lines at a point of measurement, and
a receiver configured to receive electromagnetic radiation which emerges from the flexible line at the point of measurement,
wherein the measuring set-up is configured to supply measurement data to an analyzing unit, wherein the measurement data is characteristic of the intensity of the electromagnetic radiation which enters the flexible line at the point of measurement and which emerges from the flexible line at the point of measurement;

a blood pump arranged in one of the flexible lines and configured to pump blood;
a shut-off member arranged in one of the flexible lines; and
a control and computing unit configured to operate the blood pump and the shut-off member, wherein the control and computing unit is configured to stop the blood pump for a preset interval of time and, when the blood pump is stopped, the shut-off member is at least partly closed and then opened, to change the hydrodynamic behavior of the fluid flowing in one of the flexible lines at the point of measurement,
wherein the analyzing unit is configured to analyze measurement data obtained during the change in hydrodynamic behavior, and is configured to determine the concentration of the blood constituent from the measurement data obtained during the change in hydrodynamic behavior.

8. The apparatus according to claim 7 , wherein the system of flexible lines has a blood inlet line that runs to the first chamber of the dialyzer or filter and a blood return line that leads from the first chamber of the dialyzer or filter, wherein when the hydrodynamic behavior of the blood flowing in the blood inlet line is changed, the measuring set-up is arranged on the blood inlet line, and wherein when the hydrodynamic behavior of the blood flowing in the blood return line is changed, the measuring set-up is arranged on the blood return line.

9. The apparatus according to claim 8 , wherein the pump is arranged in the blood inlet line, and wherein the apparatus further comprises:
a control and computing unit configured to change the flow rate of the blood in the blood inlet line or the blood return line.

10. The apparatus according to claim 8 , wherein the pump is arranged in the blood inlet line and the shut-off member is arranged in the blood inlet line, and the apparatus further comprises:
a control and computing unit configured to change the flow rate of the blood in the blood inlet line or the blood return line.

11. The apparatus according to claim 10 , wherein the control and computing unit is configured such that when the blood pump is stopped, the shut-off member is at least partly closed and at least partly opened more than once.

12. The apparatus according to claim 10 , wherein the control and computing unit is configured to stop the blood flow on the blood inlet line or the blood outlet line for a preset interval of time and, when the blood pump is stopped, the shut-off member is completely closed.

13. The apparatus according to claim 10 , wherein the shut-off member comprises a tube clamp arranged on the blood inlet line.

14. The system according to claim 1 , wherein the pump is arranged in the blood inlet line and the shut-off member is arranged in the blood inlet line, and the control and computing unit is configured to change the flow rate of the blood in the blood inlet line or the blood return line.

15. The system according to claim 1 , wherein the control and computing unit is configured such that when the blood pump is stopped, the shut-off member is at least partly closed and at least partly opened more than once.

16. The system according to claim 1 wherein the shut-off member comprises a tube clamp arranged on the blood inlet line.

17. The apparatus according to claim 7 , wherein the emitter is configured to emit electromagnetic radiation of a first wavelength and a second wavelength, said first wavelength and said second wavelength being different from one another.

18. The apparatus according to claim 7 , wherein the emitter is configured to emit electromagnetic radiation in different directions which are orthogonal to one another.

19. The apparatus according to claim 7 , wherein the receiver is configured to receive electromagnetic radiation from different directions which are orthogonal to one another.

20. The apparatus according to claim 7 , wherein the electromagnetic radiation comprises light of a wavelength of between 385 nm and 950 nm.

21. The apparatus according to claim 7

Assignees

• Zhang Wei
• Fresenius Medical Care De Gmbh

Inventors

• Zhang Wei

Classifications

• A61M1/16 Primary

  with membranes · CPC title

• A61B5/14557

  specially adapted to extracorporeal circuits · CPC title

• A61B5/14532

  for measuring glucose, e.g. by tissue impedance measurement · CPC title

• A61M1/361

  before treatment · CPC title

• A61M2230/30

  Blood pressure (A61M2230/04 takes precedence) · CPC title