Methods, systems, and devices for treating tinnitus with VNS pairing

Patent metadata

Field	Value
Publication number	US-9265663-B2
Application number	US-201414527253-A
Country	US
Kind code	B2
Filing date	Oct 29, 2014
Priority date	Jul 2, 2008
Publication date	Feb 23, 2016
Grant date	Feb 23, 2016

Abstract

A method of treating tinnitus comprising measuring a patient's hearing, determining the patient's hearing loss and the patient's tinnitus frequency using the measurements of the patient's hearing, programming a clinical controller with the measurements of the patient's hearing, selecting a plurality of therapeutic tones, where the therapeutic tones are selected to be at least a half-octave above or below of the patient's tinnitus frequency, setting an appropriate volume for each of the plurality of tones, repetitively playing each of the plurality of therapeutic tones, and pairing a vagus nerve stimulation pulse train with each playing of a therapeutic tone, thereby reducing the patient's perception of tinnitus.

First claim

What is claimed is:

1. A method of treating tinnitus comprising:
determining the patient's tinnitus frequency;
programming a clinical controller with the determined tinnitus frequency;
selecting a plurality of therapeutic tones;
setting an appropriate volume for each of the plurality of therapeutic tones;
repetitively playing each of the plurality of therapeutic tones; and
providing a vagus nerve stimulation pulse train with each playing of a therapeutic tone, thereby reducing the patient's perception of tinnitus, wherein
the respective therapeutic tones of the plurality of therapeutic tones are outside the range of the patient's tinnitus frequency.

2. The method of claim 1 , wherein respective tones of the plurality of therapeutic tones are respectively at one discrete tone.

3. The method of claim 1 , wherein at least some respective tones of the plurality of therapeutic tones are respectively at two or more different tones.

4. The method of claim 1 , wherein the method is implemented using a sound generator that respectively operates as a tone generator when generating at least some respective tones of the plurality of tones.

5. The method of claim 1 , wherein the action of playing each of the plurality of therapeutic tones includes:
exposing the patient to a respective tone at a volume different from that of another respective tone.

6. A method of treating tinnitus comprising:
determining the patient's tinnitus frequency;
selecting a plurality of therapeutic tones;
setting an appropriate volume for each of the plurality of tones;
repetitively playing each of the plurality of therapeutic tones; and
associating an electrical vagus nerve stimulation pulse train, with each playing of a therapeutic tone so that the stimulation pulse train occurs during the playing of a therapeutic tone, thereby reducing the patient's perception of tinnitus, wherein
the respective therapeutic tones of the plurality of therapeutic tones are outside the range of the patient's tinnitus frequency.

7. The method of claim 6 , wherein the action of repetitively playing each of the plurality of therapeutic tones includes:
exposing the patient to a respective tone at a volume different from that of another respective tone.

8. The method of claim 6 , wherein the action of repetitively playing each of the plurality of therapeutic tones includes:
playing the tones of the plurality of therapeutic tones at the same volume.

9. The method of claim 6 , further comprising:
at least one of determining a patient's hearing loss or measuring a patient's hearing.

10. A method of treating tinnitus comprising:
determining the patient's tinnitus frequency;

selecting a plurality of therapeutic tones;
setting an appropriate volume for each of the plurality of tones;
repetitively playing each of the plurality of therapeutic tones; and
timing an electrical vagus nerve stimulation pulse train with each playing of a therapeutic tone so that the stimulation pulse train occurs before the playing of a therapeutic tone, thereby reducing the patient's perception of tinnitus, wherein
the respective therapeutic tones of the plurality of therapeutic tones are outside the range of the patient's tinnitus frequency.

11. The method of claim 10 , wherein:
the therapeutic tones are selected to be at least a half-octave below the patient's tinnitus frequency.

12. The method of claim 11 , wherein the selecting a plurality of therapeutic tones is performed based on the determined tinnitus frequency.

13. The method of claim 10 , further comprising:
setting respective volumes for respective tones of the plurality of therapeutic tones exposed to the patient, wherein the respective tones exposed to the patient are exposed at the respective set volumes.

14. The method of claim 10 , wherein:
at least some tones of the plurality tones are at one discrete tone.

15. The method of claim 10 , wherein:
the selected therapeutic tones are either a half-octave above or below of the patient's tinnitus frequency.

16. A method of treating tinnitus comprising:
determining the patient's tinnitus frequency;
selecting a plurality of therapeutic tones;
setting an appropriate volume for each of the plurality of tones;
repetitively playing each of the plurality of therapeutic tones; and
pairing an electrical vagus nerve stimulation pulse train with each playing of a therapeutic tone so that the stimulation pulse train occurs after the playing of a therapeutic tone, thereby reducing the patient's perception of tinnitus, wherein
the respective therapeutic tones of the plurality of therapeutic tones are outside the range of the patient's tinnitus frequency.

17. The method of claim 16 , further comprising:
setting respective volumes for the plurality of therapeutic tones exposed to the patient, wherein respective therapeutic tones of the plurality of therapeutic tones exposed to the patient are exposed at the respective set volumes.

18. The method of claim 16 , further comprising:
measuring a patient's hearing; and
determining the patient's hearing loss and the patient's tinnitus frequency using the measurements of the patient's hearing.

19. The method of claim 18 , further comprising:
programming a clinical controller with the measurements of the patient's hearing.

20. The method of claim 19 , wherein:
the programmed clinical controller controls the pairing of the vagus nerve stimulation pulse train.

21. The method of claim 16 , further comprising:
selecting a plurality of therapeutic tones, where the therapeutic tones are selected to be at least a half-octave above or below of the patient's tinnitus frequency.

22. The method of claim 16 , wherein:
the therapeutic tones are selected to be at least a half-octave above the patient's tinnitus frequency.

Assignees

• Microtransponder Inc
• Univ Texas

Inventors

• Kilgard Michael P
• Engineer Navzer
• Pierce David Michael

Classifications

• A61N1/36178

  Burst or pulse train parameters · CPC title

• A61N1/37247

  User interfaces, e.g. input or presentation means · CPC title

• A61N1/36092

  Mental training · CPC title

• A61N1/36132

  using patient feedback · CPC title

• A61N1/36167

  Timing, e.g. stimulation onset · CPC title