Nonlinear System Identification Techniques and Devices For Discovering Dynamic And Static Tissue Properties
US-2015051513-A1 · Feb 19, 2015 · US
US9265461B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9265461-B2 |
| Application number | US-87264310-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 31, 2010 |
| Priority date | Sep 1, 2009 |
| Publication date | Feb 23, 2016 |
| Grant date | Feb 23, 2016 |
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A method for testing the effect of a skin care product includes measuring a mechanical property of skin tissue using nonlinear stochastic system identification, applying the product to the skin, repeating the measurement of the mechanical property after the application of the product, and comparing the before and after measurements to quantify the effect of the product. Measuring the mechanical property of the skin can include placing a probe against a surface of the skin, perturbing the skin with the probe using a stochastic sequence, and measuring the response of the skin to the perturbation. Perturbing the skin can include indenting the skin with the probe, extending the skin with the probe, and sliding the probe across the skin surface. The mechanical property may be indicative of skin compliance, skin elasticity, skin stiffness, or skin damping. The mechanical property can be dependent on perturbation depth and may be measured at a plurality of anatomical locations.
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What is claimed is: 1. A method for testing the effect of a skin care product, the method comprising: establishing a stochastic sequence and dynamic properties of a device such that, when the device is applied to skin tissue, a system that includes the device and skin tissue has system dynamics, including a system upper cutoff frequency and a displacement range, that enable measurement of a mechanical property of the skin tissue, the stochastic sequence being an input to the system and having an upper cutoff frequency greater than the system upper cutoff frequency but low enough such that the displacement range is sufficiently large to test depth-dependent nonlinearities of skin, the displacement range being 4 mm to 32 mm; measuring a mechanical property of the skin tissue with the device using stochastic system identification; applying the product to the skin; repeating the measurement of the mechanical property after the application of the product; and comparing the before and after measurements to quantify the effect of the product. 2. The method of claim 1 , wherein measuring the mechanical property of the skin and repeating the measurement of the mechanical property each include placing a probe of the device against a surface of the skin, perturbing the skin with the probe using the stochastic sequence, and measuring the response of the skin to the perturbation. 3. The method of claim 2 , wherein measuring the response of the skin comprises measuring displacement of the skin. 4. The method of claim 2 , wherein perturbing the skin comprises using a Lorentz force linear actuator. 5. The method of claim 2 , wherein perturbing the skin comprises indenting the skin with the probe. 6. The method of claim 2 , wherein perturbing the skin comprises extending the skin with the probe. 7. The method of claim 2 , wherein perturbing the skin comprises sliding the probe across the skin surface. 8. The method of claim 2 , further comprising modeling the probe and skin as a system comprising a linear dynamic component and a non-linear static component. 9. The method of claim 8 , wherein modeling comprises generating a non-parametric model. 10. The method of claim 8 , wherein modeling comprises generating a parametric model. 11. The method of claim 8 , wherein the non-linear component includes a Wiener static nonlinear system. 12. The method of claim 8 , wherein the linear component includes a second order mechanical system. 13. The method of claim 1 , wherein the mechanical property is indicative of skin compliance. 14. The method of claim 1 , wherein the mechanical property is indicative of skin elasticity. 15. The method of claim 1 , wherein the mechanical property is indicative of skin stiffness. 16. The method of claim 1 , wherein the mechanical property is indicative of skin damping. 17. The method of claim 1 , wherein the mechanical property is dependent on perturbation depth. 18. The method of claim 1 , wherein the mechanical property is measured at a plurality of anatomical locations. 19. The method of claim 1 , wherein the mechanical property is measured using nonlinear stochastic system identification. 20. The method of claim 1 , wherein the dynamic properties of the device include at least one of mass, damping and compliance. 21. The method of claim 1 , wherein the stochastic sequence is tailored such that a force applied to the skin with the device is less than 12 N. 22. The method of claim 1 , further comprising mathematically removing at least one of the dynamic properties of the device from the measured skin property. 23. A method for measuring a mechanical property of skin tissue, the method comprising: establishing a stochastic sequence and dynamic properties of a device such that, when the device is applied to skin tissue, a system that includes the device and skin tissue has system dynamics, including a system upper cutoff frequency and a displacement range, that enable measurement of a mechanical property of the skin tissue, the stochastic sequence being an input to the system and having an upper cutoff frequency greater than the system upper cutoff frequency but low enough such that the displacement range is sufficiently large to test depth-dependent nonlinearities of skin, the displacement range being 4 mm to 32 mm; and measuring a mechanical property of the skin tissue with the device using stochastic system identification. 24. The method of claim 23 , wherein the mechanical property is measured using nonlinear stochastic system identification. 25. The method of claim 23 , wherein the dynamic properties of the device include at least one of mass, damping and compliance. 26. The method of claim 23 , wherein the stochastic sequence is tailored such that a force applied to the skin with the device is less than 12 N. 27. The method of claim 23 , further comprising mathematically removing at least one of the dynamic properties of the device from the measured skin property.
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