Modified human four helical bundle polypeptides and their uses

US9260472B2 · US · B2

Patent metadata
FieldValue
Publication numberUS-9260472-B2
Application numberUS-87476107-A
CountryUS
Kind codeB2
Filing dateOct 18, 2007
Priority dateFeb 2, 2004
Publication dateFeb 16, 2016
Grant dateFeb 16, 2016

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Abstract

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Modified human four helical bundle (4HB) polypeptides and uses thereof are provided.

First claim

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What is claimed is: 1. An isolated four helical bundle (4HB) polypeptide chosen from the group consisting of human growth hormone, interferon, erythropoietin, and granulocyte cell stimulating factor, comprising a ribosomally incorporated para-acetyl-phenylalanine within the C-D loop of the 4HB polypeptide, wherein the 4HB polypeptide with para-acetyl-phenylalanine has at least a 2-fold increased serum half-life over the wild type 4HB polypeptide. 2. The 4HB pol…

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What does patent US9260472B2 cover?
Modified human four helical bundle (4HB) polypeptides and uses thereof are provided.
Who is the assignee on this patent?
Cho Ho Sung, Daniel Thomas O, Dimarchi Richard D, and 5 more
What technology area does this patent fall under?
Primary CPC classification C07K14/61. Mapped technology areas include Chemistry & Metallurgy.
When was this patent published?
Publication date Tue Feb 16 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).