Stable growth hormone compounds resistant to proteolytic degradation
US-9211342-B2 · Dec 15, 2015 · US
US9260472B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9260472-B2 |
| Application number | US-87476107-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 18, 2007 |
| Priority date | Feb 2, 2004 |
| Publication date | Feb 16, 2016 |
| Grant date | Feb 16, 2016 |
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Modified human four helical bundle (4HB) polypeptides and uses thereof are provided.
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What is claimed is: 1. An isolated four helical bundle (4HB) polypeptide chosen from the group consisting of human growth hormone, interferon, erythropoietin, and granulocyte cell stimulating factor, comprising a ribosomally incorporated para-acetyl-phenylalanine within the C-D loop of the 4HB polypeptide, wherein the 4HB polypeptide with para-acetyl-phenylalanine has at least a 2-fold increased serum half-life over the wild type 4HB polypeptide. 2. The 4HB pol…
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