Microfluidic system for amplifying and detecting polynucleotides in parallel
US-9080207-B2 · Jul 14, 2015 · US
US9259735B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9259735-B2 |
| Application number | US-201414317356-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 27, 2014 |
| Priority date | Mar 28, 2001 |
| Publication date | Feb 16, 2016 |
| Grant date | Feb 16, 2016 |
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The present invention provides control methods, control systems, and control software for microfluidic devices that operate by moving discrete micro-droplets through a sequence of determined configurations. Such microfluidic devices are preferably constructed in a hierarchical and modular fashion which is reflected in the preferred structure of the provided methods and systems. In particular, the methods are structured into low-level device component control functions, middle-level actuator control functions, and high-level micro-droplet control functions. Advantageously, a microfluidic device may thereby be instructed to perform an intended reaction or analysis by invoking micro-droplet control function that perform intuitive tasks like measuring, mixing, heating, and so forth. The systems are preferably programmable and capable of accommodating microfluidic devices controlled by low voltages and constructed in standardized configurations. Advantageously, a single control system can thereby control numerous different reactions in numerous different microfluidic devices simply by loading different easily understood micro-droplet programs.
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What is claimed is: 1. A system configured for controlling a microfluidic device, wherein the microfluidic device comprises a micro-channel, a reaction chamber, at least one micro-valve, and at least one heater, the system comprising: memory comprising stored instructions, the stored instructions comprising at least one actuator level function that controls a group of one or more components to achieve a particular actuator-type function, the at least one actuator level function c…
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