Production process of film and column for cation chromatography
US-9579629-B2 · Feb 28, 2017 · US
Method for production of chromatography media
US9259729B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9259729-B2 |
| Application number | US-201113642937-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 20, 2011 |
| Priority date | Apr 26, 2010 |
| Publication date | Feb 16, 2016 |
| Grant date | Feb 16, 2016 |
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- Title
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Abstract
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The present invention relates to a method and means to produce chromatography media having improved pressure-flow properties. More closely, the invention relates to bimodal particle size distribution and the use of layer functionalization as means to change pressure-flow properties of chromatography media. The invention relates to a method for production of chromatography media having improved pressure-flow properties, comprising mixing large beads/particles, comprising an inner core and an outer functionalized shell/lid, with smaller beads/particles, wherein the ratio of the particle size of large and small beads: [D 50V for large particles/D 50V for small particles]>1.2, and wherein the volume ratio of large and small beads in the column: [Total volume of large beads/Total volume beads] is in the range 0.05-0.9.
First claim
Opening claim text (preview).
The invention claimed is: 1. A method for production of chromatography media having improved pressure-flow properties, comprising mixing large beads/particles, comprising an inner core and an outer functionalized shell/lid, with smaller beads/particles, wherein the ratio of the particle size of large and small beads: [D 50V for large particles/D 50V for small particles]>3, and wherein the volume ratio of large and small beads in the column: [Total volume of large beads/Total volume beads] is in the range of from 0.1-0.2. 2. The method of claim 1 , wherein the core is porous. 3. The method of claim 1 , wherein the core is non-porous. 4. The method of claim 1 , wherein the shell of the larger particles and the small particles are functionalized with the same type of ligand. 5. The method of claim 4 , wherein the ligands are ion exchange ligands, HIC, Chelating, protein A, Affinity or RPC ligands. 6. The method of claim 1 , wherein a porous core are functionalized with a ligand that not interact with the target molecule in a sample. 7. The method of claim 1 , wherein the shell thickness (ST) of the large beads: ST<[D 50V for small particles/2].
Assignees
Inventors
Classifications
Phases chemically bonded to a substrate, e.g. to silica or to polymers · CPC title
Sorbent size or size distribution, e.g. particle size · CPC title
- B01J39/165Primary
Operations & Transport · mapped topic
Operations & Transport · mapped topic
Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group · CPC title
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- What does patent US9259729B2 cover?
- The present invention relates to a method and means to produce chromatography media having improved pressure-flow properties. More closely, the invention relates to bimodal particle size distribution and the use of layer functionalization as means to change pressure-flow properties of chromatography media. The invention relates to a method for production of chromatography media having improved …
- Who is the assignee on this patent?
- Bergstrom Jan, Johansson Bo-Lennart, Ge Healthcare Bio Sciences Ab
- What technology area does this patent fall under?
- Primary CPC classification B01J39/165. Mapped technology areas include Operations & Transport.
- When was this patent published?
- Publication date Tue Feb 16 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 6 related publications on this page (citations in our corpus or others sharing the same primary CPC).