Polymers having therapeutically active agents conjugated thereto, processes of preparing same and uses thereof
US-2015017115-A1 · Jan 15, 2015 · US
US9259482B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9259482-B2 |
| Application number | US-201314082224-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 18, 2013 |
| Priority date | May 22, 2008 |
| Publication date | Feb 16, 2016 |
| Grant date | Feb 16, 2016 |
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Conjugates of a polymer having attached thereto an angiogenesis targeting moiety and a therapeutically active agent such as an anti-cancer agent or anti-angiogenesis agent, and processes of preparing same are disclosed. Pharmaceutical compositions containing these conjugates and uses thereof in the treatment of angiogenesis-related medical conditions such as cancer and cancer metastases are also disclosed.
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What is claimed is: 1. A conjugate having the structure: wherein: x is an integer having a value such that x/(x+y+w) multiplied by 100 is in the range of from 0.01 to 99.9; y is an integer having a value such that y/(x+y+w) multiplied by 100 is in the range of from 0.01 to 99.9; and w is an integer having a value such that w/(x+y+w) multiplied by…
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