Glucagon analogues
US-2015111817-A1 · Apr 23, 2015 · US
US9259477B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9259477-B2 |
| Application number | US-201214355906-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 2, 2012 |
| Priority date | Nov 3, 2011 |
| Publication date | Feb 16, 2016 |
| Grant date | Feb 16, 2016 |
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The present invention relates, inter alia, to certain peptide conjugates, and to the use of the conjugates in the treatment of a variety of diseases or disorders, including diabetes (type 1 and/or type 2) and diabetes-related diseases or disorders.
Opening claim text (preview).
The invention claimed is: 1. A peptide conjugate having the formula I R 1 —Z a -L a -Y a —R 2 (I) wherein R 1 is H, C 1-4 alkyl, acetyl, formyl, benzoyl or trifluoroacetyl; and R 2 is OH or NH 2 ; Z a is a peptide sequence having the formula Ia His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Z9-Leu-Ser-Z12-Z13-Z14-Glu-Z16-Glu-Ala-Val-Z20-Leu-Phe-Ile-Z24-Z25-Leu-Z27-Z28 (Ia) wherein Z9 is selected from Asp and Glu; Z12 is selected from Lys, Arg and Orn; Z13 is selec…
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