Methods for treatment of cancer with an anti-tigit antagonist antibody
US-2024424092-A1 · Dec 26, 2024 · US
US9255595B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9255595-B2 |
| Application number | US-201213809330-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 16, 2012 |
| Priority date | Apr 29, 2011 |
| Publication date | Feb 9, 2016 |
| Grant date | Feb 9, 2016 |
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Techniques and architecture are disclosed for implementing an optical dome bezel to interface an optical dome/window and a housing of differing coefficients of thermal expansion (CTEs), In some embodiments, the bezel may comprise a material (e.g., Ti-6Al-4V) that is CTE-matched to the optical dome material (e.g., silicon, germanium, sapphire, ALON), thereby mitigating temperature effects on system performance. In some embodiments, the bezel may include a radially compliant flexure feature (e.g., flexure blades, spring-form S-channels), which mitigates physical stress effects (e.g., vibration, thermal expansion/contraction, etc.) on system performance. In some embodiments, the bezel may include an integral environmental sealing feature (e.g., O-ring gaskets), which protects internal optics/electronics from external environmental hazards (e.g., moisture, corrosive substances, particulates, debris). In some embodiments, the bezel may be efficiently and repeatedly removed/replaced while preserving optical system performance. Numerous configurations and variations will be apparent in light of this disclosure.
Opening claim text (preview).
What is claimed is: 1. An apparatus comprising: a mounting ring having an aperture passing therethrough from an exterior surface of the mounting ring to an opposing, interior surface thereof; a radially compliant flexure feature integral with the mounting ring such that the mounting ring and the radially compliant flexure feature constitute a monolithic piece; and an environmental sealing feature integral with the mounting ring. 2. The apparatus of claim 1 , wherein the mounting ring comprises at least one of Grade 5 titanium alloy (Ti-6Al-4V), a low-expansion iron-nickel alloy, a low-expansion stainless steel, and an aluminum-beryllium composite. 3. The apparatus of claim 1 , wherein the aperture is configured to receive a quantity of adhesive sealant for bonding an optical dome/window to the mounting ring. 4. The apparatus of claim 1 , wherein the radially compliant flexure feature comprises a plurality of flexure blades disposed along an outer perimeter of the mounting ring and extending substantially perpendicular to the interior surface of the mounting ring. 5. The apparatus of claim 4 , wherein at least one flexure blade further comprises: a flexure foot located at a distal end of the flexure blade and extending radially outward substantially parallel to the interior surface of the mounting ring; and a precision alignment feature located at the distal end of the flexure blade, positioned opposite the flexure foot, and extending radially inward substantially parallel to the interior surface of the mounting ring. 6. The apparatus of claim 1 , wherein the radially compliant flexure feature comprises a continuous spring-form S-channel integrally formed in the mounting ring. 7. The apparatus of claim 1 , wherein the environmental sealing feature comprises: a first channel integral with the interior surface of the mounting ring at a first radial distance; and a second channel integral with the interior surface of the mounting ring at a second radial distance of lesser radius than the first channel. 8. The apparatus of claim 7 , wherein at least one of the first channel and the second channel contains a sealing material that is resistant to at least one of water, rain, humidity, moisture, steam, corrosive fluids, corrosive vapors, fuels, lubricants, greases, solvents, ozone, particulates, dust, smoke, and debris over a temperature range of about −60° C. to 90° C. 9. The apparatus of claim 7 , wherein the first channel contains a fluorosilicone O-ring gasket, and the second channel contains a butyl O-ring gasket. 10. The apparatus of any of claims 1 - 9 further comprising a protective ring/sleeve configured to be received by the aperture and to protect at least one of at least a portion of the mounting ring and an optical dome/window received by the mounting ring during operative coupling of the apparatus with a housing. 11. The apparatus of claim 10 , wherein the protective ring/sleeve comprises the same material as the mounting ring. 12. A system comprising: an optical dome/window; and a bezel configured to receive the optical dome/window, wherein the bezel comprises: a mounting ring having an aperture passing therethrough from an exterior surface of the mounting ring to an opposing, interior surface thereof; a radially compliant flexure feature integral with the mounting ring such that the mounting ring and the radially compliant flexure feature constitute a monolithic piece; and an environmental sealing feature integral with the mounting ring. 13. The system of claim 12 , wherein the optical dome/window comprises at least one of aluminum oxynitride (ALON), silicon, germanium, and sapphire. 14. The system of claim 12 , wherein the optical dome/window is configured with a geometry selected from the group consisting of spherical, ellipsoidal, polyhedral, cubic, prismatic, cylindrical, planar, curvilinear, and non-planar. 15. The system of claim 12 , wherein the mounting ring comprises at least one of Grade 5 titanium alloy (Ti-6Al-4V), a low-expansion iron-nickel alloy, a low-expansion stainless steel, and an aluminum-beryllium composite. 16. The system of claim 12 , wherein the radially compliant flexure feature comprises a plurality of flexure blades positioned along an outer perimeter of the mounting ring and extending substantially perpendicular to the interior surface of the mounting ring. 17. The system of claim 16 , wherein at least one flexure blade further comprises: a flexure foot located at a distal end of the flexure blade and extending radially outward substantially parallel to the interior surface of the mounting ring; and a precision alignment feature located at the distal end of the flexure blade, positioned opposite the flexure foot, and extending radially inward substantially parallel to the interior surface of the mounting ring. 18. The system of claim 12 , wherein the radially compliant flexure feature comprises a continuous spring-form S-channel integrally formed in the mounting ring. 19. The system of claim 12 , wherein the environmental sealing feature comprises: a first channel integral with the interior surface of the mounting ring at a first radial distance; and a second channel integral with the interior surface of the mounting ring at a second radial distance of lesser radius than the first channel; wherein at least one of the first channel and the second channel contains an O-ring gasket that is resistant to at least one of water, rain, humidity, moisture, steam, corrosive fluids, corrosive vapors, fuels, lubricants, greases, solvents, ozone, particulates, dust, smoke, and debris over a temperature range of about −60° C. to 90° C. 20. The system of any of claims 12 - 19 , wherein the bezel further comprises a protective ring/sleeve configured to be received by the aperture and to protect at least one of at least a portion of the mounting ring and optical dome/window during operative coupling of the bezel with a housing. 21. The system of any of claims 12 - 19 , wherein the bezel is configured to operatively couple with a housing comprising a material having a different coefficient of thermal expansion from that of the optical dome/window, and wherein the bezel is configured to at least one of provide a substantially stress-free bezel-to-optical dome/window interface over a temperature range of about −60° C. to 90° C. and provide a low-stress bezel-to-housing interface over a temperature range of about −60° C. to 90° C. while exhibiting radially compliant flexure. 22. A system comprising: a bezel comprising: an annular mounting ring having an aperture passing therethrough from an exterior surface of the mounting ring to an opposing, interior surface thereof; a plurality of flexure blades positioned along an outer perimeter of the mounting ring, wherein the flexure blades extend substantially perpendicular to the inner surface of the mounting ring, and wherein at least one flexure blade further comprises: a flexure foot located at a distal end of the flexure blade and extending radially outward substantially parallel to the interior surface of the mounting ring; and a precision alignment feature located at the distal end of the flexure blade, positioned opposite the flexure foot, and extending radially inward substantially parallel to the interior surface of the mounting ring; a first channel formed in the interior surface of the mounting ring at a first radial distance; a fluorosilicone O-ring gasket disposed within the fir
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