Aerosol generation for stable, low-concentration delivery

Patent metadata

Field	Value
Publication number	US-9254500-B2
Application number	US-201414510262-A
Country	US
Kind code	B2
Filing date	Oct 9, 2014
Priority date	Oct 9, 2013
Publication date	Feb 9, 2016
Grant date	Feb 9, 2016

Abstract

A feed aerosol comprising detectable particles is injected into a mix-enhancing swirler. Diluting gas is also injected into the mix-enhancing swirler and mixed with the feed aerosol in a swirling motion to form an aerosol with a particle concentration no greater than 1,000 particles per liter. The aerosol is then injected into a mixing chamber, where the aerosol is mixed and dried; the inner diameter of the mixing chamber is at least twice as great as that of the swirl chamber. The aerosol is then emitted through a flow straightener that removes swirl from the flow of the aerosol and passed through a delivery conduit, where the particles are detected and counted; and the particle count is compared with a target count. The respective flows of feed aerosol and diluting gas can then be increased or decreased based on a comparison of the particle count with the target count.

First claim

What is claimed is:

1. A method for generating a stable, low-concentration aerosol, comprising:
generating a flow of a feed aerosol comprising detectable particles;
injecting the flow of feed aerosol into a mix-enhancing swirler;
injecting a flow of a diluting gas into the mix-enhancing swirler and mixing with the feed aerosol in a swirling motion in a swirl chamber of the mix-enhancing swirler to form a low-concentration aerosol with a particle concentration of no greater than 1,000 particles per liter;
injecting the low-concentration aerosol from the mix-enhancing swirler into an inlet of a substantially cylindrical mixing chamber;
mixing and drying the low-concentration aerosol in the mixing chamber;
emitting the low-concentration aerosol from an outlet of the mixing chamber through a flow straightener that removes swirl from the flow of the low-concentration aerosol;
passing the low-concentration aerosol from the flow straightener through a delivery conduit;
detecting and counting the particles in the delivery conduit to produce a particle count;
comparing the particle count with a target count;
if the particle count is less than the target count, increasing the flow of feed aerosol and decreasing the flow of diluting gas into the mix-enhancing swirler; and
if the particle count is greater than the target count, decreasing the flow of feed aerosol and increasing the flow of diluting gas into the mix-enhancing swirler,
wherein the mixing chamber has an inner diameter, measured orthogonally to a flow path from the inlet to the outlet, that is at least twice as great as an inner diameter of the swirl chamber of the mix-enhancing swirler.

2. The method of claim 1 , further comprising:
injecting the low-concentration aerosol from the delivery conduit into a particle-detection apparatus;
again detecting and counting the particles in the low-concentration aerosol, this time with the particle-detection apparatus; and
comparing the particle count from the particle-detection apparatus with the particle count taken in the delivery conduit to evaluate the accuracy of particle detection and counting in the particle-detection apparatus.

3. The method of claim 1 , wherein the feed aerosol is generated with a nebulizer.

4. The method of claim 1 , wherein the particle concentration in the low-concentration aerosol is in a range from 10-500 particles per liter.

5. The method of claim 4 , wherein the particle concentration in the low-concentration aerosol has a noise level no greater than 6% averaged over one minute at 10 ppl.

6. The method of claim 4 , wherein the particle concentration in the low-concentration aerosol has a noise level no greater than 2% averaged over one minute at 100 ppl.

7. The method of claim 1 , wherein the flow of feed aerosol is injected into the mix-enhancing swirler along a first axis, wherein the flow of diluting gas is injected into the mix-enhancing swirler along a second axis, and wherein the first axis is substantially orthogonal to the first axis.

8. The method of claim 7 , wherein the mix-enhancing swirler comprises a substantially cylindrical outer swirl chamber wall, and wherein the diluting gas is injected at a perimeter of the swirl chamber at an angle that is substantially tangential to the outer swirl chamber wall.

9. The method of claim 8 , wherein the mix-enhancing swirler further comprises an inner apertured swirl inducer that defines an inner channel into which the feed aerosol is injected and an outer annular channel around which the diluting gas swirls, and wherein the inner apertured swirl inducer further defines apertures through which the diluting gas passes from the outer annular channel to the inner channel where the diluting gas dilutes the feed aerosol to form the low-concentration aerosol.

10. The method of claim 1 , wherein the flow straightener defines a plurality of parallel flow channels.

11. The method of claim 1 , wherein the particles are detected and counted in the delivery conduit as the low-concentration aerosol flows through the conduit at a rate of at least 28.3 liters per minute.

12. The method of claim 1 , wherein the particle count is measured over a window of at least 30 seconds.

13. The method of claim 12 , wherein the particle count is compared with the target count at increments that are shorter than the window over which the particles are counted to produce the particle count.

14. The method of claim 1 , wherein the flows of feed aerosol and diluting gas are controlled using a proportional-integral-differential feedback controller.

15. The method of claim 1 , wherein the particles include a pharmaceutical compound, and further comprising delivering the low-concentration aerosol from the delivery conduit to a living organism in which the pharmaceutical compound will produce a beneficial effect at the low concentration.

16. The method of claim 1 , wherein the particles include a compound that is harmful to an organism, and further comprising delivering the low-concentration aerosol from the delivery conduit to a living organism in which the compound will produce a harmful effect at the low concentration, the method further comprising evaluating toxicity or other adverse effects on the organism from exposure to the compound in the low-concentration aerosol.

17. The method of claim 1 , further comprising:
diverting the low-concentration aerosol to a purge section and filtering particulates from the low-concentration aerosol in the purge section while the flows of the feed aerosol and the diluting gas are adjusted until the particle count in the low-concentration aerosol matches the target count; then
redirecting the flow of low-concentration aerosol from the purge section to an outlet of the delivery conduit.

18. The method of claim 1 , wherein the particles are detected and counted using an isokinetic probe.

19. An aerosol generator for generating a stable, low-concentration aerosol, the aerosol generator comprising:
a source of a feed aerosol;
a source of a diluting gas;
a mix-enhancing swirler in communication both with the source of feed aerosol along a first axis and with the source of diluting gas along a second axis oriented at an angle distinct from that of the first axis, wherein the mix-enhancing swirler is configured to generate a swirling low-concentration aerosol formed of the feed aerosol and the diluting gas;
a mixing chamber in communication with the mix-enhancing swirler and configured to mix and dry the low-concentration aerosol;
a flow straightener in connection with the mixing chamber and configured to straighten flow of the low-concentration aerosol from the mixing chamber;
a delivery conduit configured to receive the straightened flow of the low-concentration aerosol from the flow straightener; and
a particle detector configured to detect and count particles in the low-concentration aerosol flow through the delivery conduit, wherein the particle detector is in electronic communication with the source of feed aerosol and with the source of diluting gas to control flow of the feed aerosol and the diluting gas based on a count of the particles by the particle detector.

Assignees

• Massachusetts Inst Technology
• Us Navy
• Us Navy

Inventors

• Linnell Jesse Allen
• Vian Trina Rae
• Morency Joseph Renard
• Dai Anlong
• Bury Mark Eric
• Sebastian Thomas
• Aguilar Carlos Andres
• Lacirignola Joseph John
• Eversole Jay D

Classifications

• G01N2001/2223

  aerosol sampling devices · CPC title

• G01N15/06 Primary

  Investigating concentration of particle suspensions (by weighing G01N5/00; investigating sedimentation of particle suspensions G01N15/04; investigating individual particles G01N15/10) · CPC title

• B05B7/0483

  with gas and liquid jets intersecting in the mixing chamber · CPC title

• B05B1/262

  with fixed deflectors · CPC title

• A61M15/00

  Inhalators {(drug delivery in endotracheal tubes A61M16/04)} · CPC title