Immunogenic composition
US-2024238398-A1 · Jul 18, 2024 · US
Compositions and methods for detecting microbial infections
US9250239B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9250239-B2 |
| Application number | US-201414175001-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 7, 2014 |
| Priority date | Sep 10, 2009 |
| Publication date | Feb 2, 2016 |
| Grant date | Feb 2, 2016 |
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Abstract
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Provided herein are vaccine compositions for control of Trypanosoma cruzi infection and Chagas disease. The compositions comprise plasmids encoding o GPI-anchored genes ASP-2, TcG-1, TcG2 and TcG4 from Trypanosoma cruzi ; plasmids encoding cytokines IL12 and GM-CSF; and plasmids encoding a gene expression system. Certain vaccine compositions comprise recombinant proteins, selected from TcG-1, TcG2 and TcG4 from Trypanosoma cruzi . In another vaccination strategy, the recombinant proteins are replaced by lysates comprising Trypanosoma rangeli cells. Further provided herein are diagnosis compositions comprising 1) recombinant proteins, selected from TcG-1, TcG2 and TcG4 from Trypanosoma cruzi ; 2) antibodies that specifically binds the TcG-1, TcG2 and TcG4 proteins; 3) sense and antisense polynucleotide sequences that encode the TcG-1, TcG2 and TcG4 proteins. Said compositions can be used in diagnosing and/or evaluating efficacy of treatments against Trypanosoma cruzi infection. A diagnosis kit, and methods of diagnosing and/or treating Trypanosoma cruzi infection are also provided.
First claim
Opening claim text (preview).
What is claimed is: 1. A method for detecting Trypanosoma cruzi infection in a subject, said method comprising the steps of: contacting a sample from a subject that has not been administered a vaccine comprising a Trypanosoma cruzi TcG-1 protein, a Trypanosoma cruzi TcG-2 protein, or a Trypanosoma cruzi TcG-4 protein with a composition comprising an isolated Trypanosoma cruzi TcG-1 protein, an isolated Trypanosoma cruzi TcG-2 protein, or an isolated Trypanosoma cruzi…
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Classifications
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
- A61K39/005Primary
Human Necessities · mapped topic
Human Necessities · mapped topic
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- What does patent US9250239B2 cover?
- Provided herein are vaccine compositions for control of Trypanosoma cruzi infection and Chagas disease. The compositions comprise plasmids encoding o GPI-anchored genes ASP-2, TcG-1, TcG2 and TcG4 from Trypanosoma cruzi ; plasmids encoding cytokines IL12 and GM-CSF; and plasmids encoding a gene expression system. Certain vaccine compositions comprise recombinant proteins, selected from TcG-1…
- Who is the assignee on this patent?
- Garg Nisha J, Univ Texas
- What technology area does this patent fall under?
- Primary CPC classification A61K39/005. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Feb 02 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).