Anti-cd47 antibody for combined treatment of blood tumor
US-2024269278-A1 · Aug 15, 2024 · US
US9249232B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9249232-B2 |
| Application number | US-30705107-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 26, 2007 |
| Priority date | Jul 3, 2006 |
| Publication date | Feb 2, 2016 |
| Grant date | Feb 2, 2016 |
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The present invention relates to improved methods for the selection of appropriate human acceptor framework regions for non-human (donor) antibodies and methods for obtaining humanized antibodies of high affinity using such acceptor frameworks.
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The invention claimed is: 1. A method for obtaining at least one humanized antibody with specificity for a selected antigen comprising: (a) providing multiple donor antibody V H and/or V L region sequences each with specificity for the selected antigen; (b) selecting for each donor region sequence of step (a), an appropriate human V H region acceptor framework sequence and/or an appropriate human V L region acceptor framework sequence, wherein selection of the human acceptor…
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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