Framework selection

US9249232B2 · US · B2

Patent metadata
FieldValue
Publication numberUS-9249232-B2
Application numberUS-30705107-A
CountryUS
Kind codeB2
Filing dateJun 26, 2007
Priority dateJul 3, 2006
Publication dateFeb 2, 2016
Grant dateFeb 2, 2016

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  1. Title

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  2. Abstract

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  4. Key dates

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  5. First independent claim

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Abstract

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The present invention relates to improved methods for the selection of appropriate human acceptor framework regions for non-human (donor) antibodies and methods for obtaining humanized antibodies of high affinity using such acceptor frameworks.

First claim

Opening claim text (preview).

The invention claimed is: 1. A method for obtaining at least one humanized antibody with specificity for a selected antigen comprising: (a) providing multiple donor antibody V H and/or V L region sequences each with specificity for the selected antigen; (b) selecting for each donor region sequence of step (a), an appropriate human V H region acceptor framework sequence and/or an appropriate human V L region acceptor framework sequence, wherein selection of the human acceptor…

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Frequently asked questions

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What does patent US9249232B2 cover?
The present invention relates to improved methods for the selection of appropriate human acceptor framework regions for non-human (donor) antibodies and methods for obtaining humanized antibodies of high affinity using such acceptor frameworks.
Who is the assignee on this patent?
Adams Ralph, Lawson Alastair David Griffiths, Popplewell Andrew George, and 2 more
What technology area does this patent fall under?
Primary CPC classification C07K16/464. Mapped technology areas include Chemistry & Metallurgy.
When was this patent published?
Publication date Tue Feb 02 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).