Neurostimulator configured to sense evoked potentials in peripheral nerves

Patent metadata

Field	Value
Publication number	US-9248279-B2
Application number	US-201414322716-A
Country	US
Kind code	B2
Filing date	Jul 2, 2014
Priority date	Jul 2, 2013
Publication date	Feb 2, 2016
Grant date	Feb 2, 2016

Abstract

A method of providing stimulation therapy to a patient includes performing first and second calibration processes in first and second patient posture states, respectively. The first and second calibration processes respectively associates a sensation experienced by a patient, in the respective patient posture states, with first and second amounts of an evoked potential, respectively, and also with first and second values of a stimulation parameter to achieve the first and second amounts of evoked potential, respectively. Thereafter, a current patient posture state is detected. If the current patient posture state is detected as the first patient posture state, stimulation therapy is applied to the patient using the first value of the stimulation parameter as an initial value. If the current patient posture state is detected as the second patient posture state, stimulation therapy is applied to the patient using the second value of the stimulation parameter as the initial value.

First claim

What is claimed is:

1. A method of providing a stimulation therapy to a patient, the method comprising:
performing a first calibration process in a first patient posture state, wherein the first calibration process associates a sensation experienced by a patient, in the first patient posture state, with a first amount of an evoked potential and a first value of a stimulation parameter for the stimulation therapy to achieve the first amount of evoked potential;
performing a second calibration process in a second patient posture state, wherein the second calibration process associates the sensation experienced by a patient, in the second patient posture state, with a second amount of the evoked potential and a second value of the stimulation parameter for the stimulation therapy to achieve the second amount of evoked potential;
detecting, after the first and second calibration processes have been performed, a current patient posture state;
if the current patient posture state is detected as the first patient posture state, applying the stimulation therapy to the patient using the first value of the stimulation parameter as an initial value; and
if the current patient posture state is detected as the second patient posture state, applying the stimulation therapy to the patient using the second value of the stimulation parameter as the initial value.

2. The method of claim 1 , further comprising: monitoring the evoked potential in the current patient posture state, and wherein:
the applying of the stimulation therapy in the first patient posture state comprises adjusting the initial value of the stimulation parameter until the first amount of the evoked potential is reached; and
the applying of the stimulation therapy in the second patient posture state comprises adjusting the initial value of the stimulation parameter until the second amount of the evoked potential is reached.

3. The method of claim 1 , wherein the stimulation parameter includes one of:
stimulation pulse amplitude or stimulation pulse width.

4. The method of claim 1 , further comprising: storing results of the first and second calibration processes in an electronic storage.

5. The method of claim 1 , wherein the first and second calibration processes each comprise:
delivering stimulation pulses to the patient, wherein the delivering includes ramping up or down a value of the stimulation parameter;
measuring a respective amount of evoked potential in response to each stimulation pulse having a different value of the stimulation parameter;
prompting the patient to indicate a plurality of sensations experienced by the patient in response to the stimulation pulses, the plurality of sensations experienced including paresthesia; and
recording the respective amount of evoked potential corresponding to each of the plurality of sensations experienced by the patient and the value of the stimulation parameter that resulted in the respective amount of evoked potential.

6. The method of claim 5 , wherein the sensations experienced by the patient comprise: initial perception of paresthesia, comfortable paresthesia, optimal paresthesia coverage for areas of pain, and uncomfortable stimulation.

7. The method of claim 1 , wherein the detecting is performed automatically via one or more sensors and without input from the patient.

8. The method of claim 1 , further comprising:
performing one or more additional calibration processes in one or more additional patient posture states, wherein the one or more additional calibration processes each associate the sensation experienced by the patient, in the respective one or more additional patient posture states, with a respective amount of the evoked potential and a respective value of the stimulation parameter for the stimulation therapy to achieve the respective amount of evoked potential; and
in response to the current patient posture state being detected as one of the one or more additional patient posture states, applying the stimulation therapy to the patient using the corresponding respective value of the stimulation parameter as the initial value.

9. A medical system for stimulating a patient, the medical system comprising:
an electronic storage configured to store:
an association of a sensation experienced by the patient in a first patient posture state with a first amount of an evoked potential and a first value of a stimulation parameter for a stimulation therapy to cause the first amount of evoked potential; and
an association of a sensation experienced by the patient in a second patient posture state with a second amount of the evoked potential and a second value of the stimulation parameter for the stimulation therapy to cause the second amount of evoked potential;

one or more sensors configured to detect a present patient posture state;
a microcontroller coupled to the one or more sensors and the electronic storage; and
stimulation circuitry configured to generate, in response to instructions from the microcontroller:
a first stimulation therapy using the first value as an initial value of the stimulation parameter in response to a detection of the patient being in the first patient posture state; and
a second stimulation therapy using the second value as the initial value of the stimulation parameter in response to a detection of the patient being in the second patient posture state.

10. The medical system of claim 9 , wherein at least the microcontroller and the stimulation circuitry are integrated within a neurostimulator, and further comprising:
an electronic programmer configure to provide programming instructions for the neurostimulator.

11. The medical system of claim 10 , further comprising: one or more electrode-containing leads that are coupled to the neurostimulator, the leads being configured to deliver the first or second stimulation therapies to a target nerve site.

12. The medical system of claim 10 , further comprising: monitoring circuitry coupled to the microcontroller and configured to monitor the evoked potential from a nerve site in response to the first or second stimulation therapies;
and wherein, in response to instructions from the microcontroller or from the electronic programmer:
if the patient is in the first patient posture state, the stimulation circuitry adjusts the stimulation parameter until the monitoring circuitry reports that the first amount of evoked potential is measured; and
if the patient is in the second patient posture state, the stimulation circuitry adjusts the stimulation parameter until the monitoring circuitry reports that the second amount of evoked potential is measured.

13. The medical system of claim 9 , wherein the stimulation parameter includes one of: stimulation pulse amplitude or stimulation pulse width.

14. The medical system of claim 9 , wherein the electronic storage is further configured to store a plurality of associations of a plurality of additional sensations experienced by the patient in the first and second patient posture states with respective amounts of the evoked potential and respective values of the stimulation parameter to cause the respective amounts of evoked potential.

15. The medical system of claim 14 , wherein the sensation and the plurality of additional sensations experienced by the patient include two or more of the following sensations: an initial perception of paresthesia, a comfortable paresthesia, an optimal paresthesia coverage for areas of pain, and an uncomfortable stimulation sensation.

16. A medical device for providing a stimulation therapy to a patient, the medical dev

Assignees

• Greatbatch Ltd

Inventors

• Chen Joey
• Bradley Kerry
• Halberg Leslie

Classifications

• A61B8/0841

  for locating instruments · CPC title

• A61N1/37252

  Details of algorithms or data aspects of communication system, e.g. handshaking, transmitting specific data or segmenting data · CPC title

• A61N1/36071

  Pain · CPC title

• A61N1/36139

  with automatic adjustment · CPC title

• A61N1/36021

  for treatment of pain · CPC title