Methods and compositions for cancer treatment
US-2024424094-A1 · Dec 26, 2024 · US
Sequence-specific MRNA interferase and uses thereof
US9243234B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9243234-B2 |
| Application number | US-201214236947-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 3, 2012 |
| Priority date | Aug 4, 2011 |
| Publication date | Jan 26, 2016 |
| Grant date | Jan 26, 2016 |
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- Title
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Abstract
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The present invention provides an improved and specific mRNA interferase and related methods of protein-based mRNA interference.
First claim
Opening claim text (preview).
What is claimed is: 1. An isolated polypeptide comprising an amino acid sequence that is at least 95% identical to the sequence of SEQ ID NO: 1. 2. The polypeptide of claim 1 , having an mRNA interferase activity. 3. The polypeptide of claim 1 , wherein the amino acid sequence is at least 99% identical to the sequence of SEQ ID NO: 1. 4. The polypeptide of claim 3 , wherein the amino acid sequence comprises the sequence of SEQ ID NO: 1. 5. The polypeptide of claim 1 , wherein the polypeptide has an activity of cleaving an RNA sequence having the target sequence of UUACUCA. 6. A composition comprising the polypeptide of claim 1 and a carrier. 7. A kit comprising the polypeptide of claim 1 and a buffer.
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Classifications
Methods for sequencing · CPC title
- C12N9/22Primary
Ribonucleases {[RNase]; Deoxyribonucleases [DNase]} · CPC title
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Frequently asked questions
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- What does patent US9243234B2 cover?
- The present invention provides an improved and specific mRNA interferase and related methods of protein-based mRNA interference.
- Who is the assignee on this patent?
- Inouye Masayori, Yamaguchi Yoshihiro, Univ Rutgers
- What technology area does this patent fall under?
- Primary CPC classification C12N9/22. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jan 26 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).